Skip to main content
HeartCited

L-Citrulline
L-Citrulline

amino_acid

别名: Citrulline, Citrulline Malate, L-Citrulline DL-Malate

<\/script>\n
`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dl\u002Dcitrulline'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    






    
    

        
        
        

            

  
About





            

                
L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic first-pass metabolism and maintaining sustained plasma arginine levels more effectively than direct arginine supplementation. A 2019 meta-analysis of 7 RCTs found L-citrulline at 3-6g/day significantly reduced systolic blood pressure by 4.1 mmHg.

            

        

        

        
        
        

            

  
How It Works





            

                
Converted to L-arginine in the kidneys bypassing hepatic first-pass metabolism, maintaining sustained plasma arginine levels; this recycling pathway maintains nitric oxide production more effectively than direct arginine supplementation; citrulline also buffers ammonia during high-demand cardiac states.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    7
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
  • 
                    
                    Generally well-tolerated
                
    • 
                
                
  • 
                    
                    Mild gastrointestinal discomfort at high doses
                
    • 
                
                
  • 
                    
                    Heartburn (rare)
                
    • 
                
            

        

        

        
        
        

            

  
Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    Antihypertensives (additive blood pressure lowering)
                
    • 
                
                
  • 
                    
                    PDE5 inhibitors (excessive vasodilation risk)
                
    • 
                
                
  • 
                    
                    Nitrates (excessive vasodilation risk)
                
    • 
                
            

            

                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    L-Arginine
                    
                
                
                
                    Taurine
                    
                
                
                
                    Nattokinase
                    
                
                
            

        

        
    


    
    












    

        FDA 免责声明:
        这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。