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L-Citrulline
L-Citrulline

amino_acid

También conocido como: Citrulline, Citrulline Malate, L-Citrulline DL-Malate

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About





            

                
L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic first-pass metabolism and maintaining sustained plasma arginine levels more effectively than direct arginine supplementation. A 2019 meta-analysis of 7 RCTs found L-citrulline at 3-6g/day significantly reduced systolic blood pressure by 4.1 mmHg.

            

        

        

        
        
        

            

  
How It Works





            

                
Converted to L-arginine in the kidneys bypassing hepatic first-pass metabolism, maintaining sustained plasma arginine levels; this recycling pathway maintains nitric oxide production more effectively than direct arginine supplementation; citrulline also buffers ammonia during high-demand cardiac states.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                Condición
                                Calificación
                                Estudios
                                Participantes
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    7
                                
                                
                                    400
                                
                                
                                    
                                        Ver →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated
                
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                    Mild gastrointestinal discomfort at high doses
                
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                    Heartburn (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Antihypertensives (additive blood pressure lowering)
                
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                    PDE5 inhibitors (excessive vasodilation risk)
                
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                    Nitrates (excessive vasodilation risk)
                
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                Informe siempre a su profesional de salud sobre todos los suplementos que toma.Siempre informe a su profesional de salud sobre todos los suplementos que toma.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    L-Arginine
                    
                
                
                
                    Taurine
                    
                
                
                
                    Nattokinase
                    
                
                
            

        

        
    


    
    












    

        Aviso legal FDA:
        Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.