What is the recommended dosage for L-Citrulline?

L Citrulline: 3,000-6,000 mg/day; Citrulline Malate: 6,000-8,000 mg/day; Blood Pressure Support: 3,000 mg/day

What are the side effects of L-Citrulline?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare).

What is L-citrulline and how may it support cardiovascular health?

L-citrulline is an amino acid that is converted to L-arginine in the kidneys, raising plasma arginine and nitric oxide levels more effectively than arginine itself. Clinical studies suggest it may improve endothelial function, reduce arterial stiffness, and modestly lower blood pressure.

What dosage of L-citrulline has been studied for cardiovascular outcomes?

Clinical trials have used 3–6 grams of L-citrulline per day, or citrulline malate at 6–8 grams daily. Blood pressure benefits were observed at doses of 3+ grams daily for 4–8 weeks. L-citrulline raises arginine levels more sustainably than L-arginine supplementation due to bypassing first-pass metabolism.

What are the potential side effects of L-citrulline?

L-citrulline is generally well tolerated with few reported side effects. Mild gastrointestinal discomfort may occur at higher doses. As a nitric oxide precursor, it may enhance the effects of blood pressure medications and nitrates (including PDE5 inhibitors like sildenafil). Individuals on antihypertensives should consult a healthcare provider.

L-Citrulline
L-Citrulline

amino_acid

다른 이름: Citrulline, Citrulline Malate, L-Citrulline DL-Malate

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L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic first-pass metabolism and maintaining sustained plasma arginine levels more effectively than direct arginine supplementation. A 2019 meta-analysis of 7 RCTs found L-citrulline at 3-6g/day significantly reduced systolic blood pressure by 4.1 mmHg.

How It Works

Converted to L-arginine in the kidneys bypassing hepatic first-pass metabolism, maintaining sustained plasma arginine levels; this recycling pathway maintains nitric oxide production more effectively than direct arginine supplementation; citrulline also buffers ammonia during high-demand cardiac states.

Evidence For Conditions

건강 상태	등급	연구	참여자
High Blood Pressure (Hypertension)	C	7	400	보기 →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort at high doses
Heartburn (rare)

Drug & Supplement Interactions

Antihypertensives (additive blood pressure lowering)
PDE5 inhibitors (excessive vasodilation risk)
Nitrates (excessive vasodilation risk)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

L-Arginine Taurine Nattokinase

핵심 정보

용량: L_Citrulline: 3,000-6,000 mg/day; Citrulline_Malate: 6,000-8,000 mg/day; Blood_Pressure_Support: 3,000 mg/day
제형: capsule powder tablet
천연 원료: Watermelon (highest food source, especially rind), Cucumbers, Pumpkin, Squash
상한 섭취량: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
권장 복용 시간: On empty stomach; divide doses for sustained arginine elevation

근거 요약

High Blood Pressure (Hypertension) C

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.