What is the recommended dosage for L-Arginine?

Endothelial Function: 3,000-6,000 mg/day; Blood Pressure Support: 6,000-10,000 mg/day divided BID-TID

What are the side effects of L-Arginine?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern).

What is L-arginine and how may it support cardiovascular health?

L-arginine is an amino acid and precursor to nitric oxide (NO), a molecule that relaxes blood vessels. Clinical studies suggest L-arginine supplementation may modestly reduce blood pressure and improve endothelial function in certain populations. However, the VINTAGE MI trial found no benefit and potential harm in post-heart attack patients.

What dosage of L-arginine has been studied for cardiovascular health?

Clinical trials have used 3–12 grams of L-arginine per day, often divided into two or three doses. Blood pressure studies typically used 4–6 grams daily for 2–12 weeks. Endothelial function improvements have been observed at doses of 6–10 grams daily. Higher doses are more likely to cause gastrointestinal side effects.

What are the potential side effects of L-arginine?

Common side effects include nausea, abdominal pain, bloating, and diarrhea. L-arginine should be avoided by individuals who have had a recent heart attack (based on the VINTAGE MI trial). It may lower blood pressure and interact with antihypertensives and nitrates. L-arginine may reactivate herpes simplex virus in susceptible individuals.

L-Arginine
L-Arginine

amino_acid

다른 이름: Arginine, L-Arg, Arginine Hydrochloride, Arginine Alpha-Ketoglutarate

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L-Arginine is the direct substrate for endothelial nitric oxide synthase (eNOS), the enzyme that produces nitric oxide — the primary endogenous vasodilator. A 2011 meta-analysis of 11 RCTs found L-arginine reduced systolic blood pressure by 5.39 mmHg. However, the VINTAGE MI trial was terminated early due to a trend toward increased mortality in post-MI patients, so L-arginine should be avoided in acute coronary syndromes.

How It Works

Direct substrate for endothelial nitric oxide synthase (eNOS), which produces nitric oxide (NO) — the primary endogenous vasodilator; NO activates soluble guanylate cyclase increasing cGMP causing smooth muscle relaxation; also inhibits platelet adhesion and aggregation; reduces endothelin-1 expression.

Evidence For Conditions

건강 상태	등급	연구	참여자
Endothelial Dysfunction	C	11	600	보기 →
Heart Failure	D	3	150	보기 →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea, bloating)
Hypotension at high doses
Worsening of herpes simplex (arginine promotes viral replication)
Potential harm in acute post-MI patients (VINTAGE MI concern)

Drug & Supplement Interactions

Antihypertensives (additive blood pressure lowering)
PDE5 inhibitors (sildenafil — excessive vasodilation risk)
Nitrates (excessive vasodilation risk)
Anticoagulants (may have mild antiplatelet effect)
Potassium-sparing diuretics (arginine may increase potassium levels)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

L-Citrulline Taurine Nattokinase

핵심 정보

용량: Endothelial_Function: 3,000-6,000 mg/day; Blood_Pressure_Support: 6,000-10,000 mg/day divided BID-TID
제형: capsule tablet powder
천연 원료: Turkey, Pork, Chicken, Pumpkin seeds, Soybeans, Peanuts, Spirulina
상한 섭취량: Not formally established; GI discomfort common above 10,000 mg/day
권장 복용 시간: On empty stomach for best absorption; divide doses throughout the day

근거 요약

Endothelial Dysfunction C

Heart Failure D

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.