L-Arginine 관련 심부전
D 연구 예비 연구(실험실 연구, 증례 보고)만 존재합니다.Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
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D
결론
Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
Key Study Findings
Review
Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Humans (general)
animal_study
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
vs: Placebo
효과: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in
not_reported
In Vitro
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
Dose: astaxanthin
vs: L-NAME-induced preeclamptic rats
Outcome: oxidative stress and blood pressure
효과: reduced ROS and improved cell survival
None
대상 집단: Preeclamptic rat model and HUVECs
In Vitro
1.0 weeks
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
Dose: 10 mg/kg
vs: None
Outcome: anxiety
효과: None
p < 0.05
대상 집단: patients with anxiety
Other
1.0 weeks
Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …
Dose: None
vs: None
Outcome: Nitric oxide modulation mediates the protective effect of …
효과: None
p<0.05
대상 집단: None
Review
Immunonutrition.
Dose: Glutamine, omega-3, antioxidants, arginine
vs: None
Outcome: Immune function and clinical outcomes
효과: None
None
대상 집단: Surgical, ICU, cancer, Crohn's disease patients
Key Statistics
3
연구
150
참여자
↔
Mixed
D
등급
Referenced Papers
Advances in experimental …
2021
206 인용
Journal of ethnopharmacology
2021
18 인용
Molecular medicine reports
2016
48 인용
Indian journal of …
2011
11 인용
Pharmacological reports : …
2008
Immunonutrition.
Review
Current opinion in …
2005
22 인용
Arginine and cancer.
Review
The Journal of …
2004
181 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- endothelialfunction:
- 3,000-6,000 mg/day
- bloodpressuresupport:
- 6,000-10,000 mg/day divided BID-TID
상한량: Not formally established; GI discomfort common above 10,000 mg/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) | -- | Positive | -- |
| astaxanthin | -- | Positive | -- |
| 10 mg/kg | 1.0 weeks | Positive | -- |
| None | 1.0 weeks | Mixed | -- |
| Glutamine, omega-3, antioxidants, arginine | -- | Positive | -- |
| L-arginine | -- | Mixed | -- |
권장 복용 시간: On empty stomach for best absorption; divide doses throughout the day
Safety & Side Effects
보고된 부작용
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Hypotension at high doses
- ⚠ Worsening of herpes simplex (arginine promotes viral replication)
- ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)
알려진 상호작용
- ● Antihypertensives (additive blood pressure lowering)
- ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
- ● Nitrates (excessive vasodilation risk)
- ● Anticoagulants (may have mild antiplatelet effect)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
일일 최대 섭취 허용량: Not formally established; GI discomfort common above 10,000 mg/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does L-Arginine help with 심부전?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support 심부전 management. Our evidence grade is D (Very Early Research).
How much L-Arginine should I take for 심부전?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Arginine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Arginine and 심부전?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
관련 다른 성분: 심부전
L-Arginine 다른 건강 상태에 대한 근거
References
- [1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
- [3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
- [4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
- [5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
- [6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
- [7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.