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L-Arginine 관련 심부전

D 연구 예비 연구(실험실 연구, 증례 보고)만 존재합니다.

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

D

결론

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

animal_study
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo 효과: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported
In Vitro
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure 효과: reduced ROS and improved cell survival

대상 집단: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
Dose: 10 mg/kg Outcome: anxiety p < 0.05

대상 집단: patients with anxiety

Review
Immunonutrition.
Dose: Glutamine, omega-3, antioxidants, arginine Outcome: Immune function and clinical outcomes

대상 집단: Surgical, ICU, cancer, Crohn's disease patients

Review
Arginine and cancer.
Dose: L-arginine Outcome: Cancer biology and NO role

Key Statistics

3

연구

150

참여자

↔

Mixed

D

등급

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other
Advances in experimental … 2021 206 인용
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other
Journal of ethnopharmacology 2021 18 인용
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other
Molecular medicine reports 2016 48 인용
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other
Indian journal of … 2011 11 인용
Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other
Pharmacological reports : … 2008
Immunonutrition. Review
Current opinion in … 2005 22 인용
Arginine and cancer. Review
The Journal of … 2004 181 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

endothelialfunction:
3,000-6,000 mg/day
bloodpressuresupport:
6,000-10,000 mg/day divided BID-TID

상한량: Not formally established; GI discomfort common above 10,000 mg/day

연구에서 사용된 용량

용량 기간 효과 N
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) -- Positive --
astaxanthin -- Positive --
10 mg/kg 1.0 weeks Positive --
Glutamine, omega-3, antioxidants, arginine -- Positive --
L-arginine -- Mixed --

권장 복용 시간: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

보고된 부작용

  • ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
  • ⚠ Hypotension at high doses
  • ⚠ Worsening of herpes simplex (arginine promotes viral replication)
  • ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

알려진 상호작용

  • ● Antihypertensives (additive blood pressure lowering)
  • ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
  • ● Nitrates (excessive vasodilation risk)
  • ● Anticoagulants (may have mild antiplatelet effect)
  • ● Potassium-sparing diuretics (arginine may increase potassium levels)

일일 최대 섭취 허용량: Not formally established; GI discomfort common above 10,000 mg/day

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does L-Arginine help with 심부전?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support 심부전 management. Our evidence grade is D (Very Early Research).
How much L-Arginine should I take for 심부전?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Arginine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Arginine and 심부전?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

L-Arginine 다른 건강 상태에 대한 근거

내피 기능 장애 C

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References

  
    
    
    
  1. 
      [1]
      Guoyao Wu et al..
      Adv Exp Med Biol.
      2021.
      Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
      doi:10.1007/978-3-030-74180-8_10
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Priya Pathak et al..
      J Ethnopharmacol.
      2021.
      Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
      doi:10.1016/j.jep.2021.114296
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Rong-Rong Xuan et al..
      Mol Med Rep.
      2016.
      Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
      doi:10.3892/mmr.2016.5569
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Anil Kumar et al..
      Indian J Pharmacol.
      2011.
      Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
      doi:10.4103/0253-7613.81506
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Anil Kumar et al..
      Pharmacol Rep.
      2008.
      Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.
      
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Robert F Grimble.
      Curr Opin Gastroenterol.
      2005.
      Immunonutrition.
      doi:10.1097/01.mog.0000153360.90653.82
      PubMed
    
    7. 
    
    
  7. 
      [7]
      D Scott Lind.
      J Nutr.
      2004.
      Arginine and cancer.
      doi:10.1093/jn/134.10.2837S
      PubMed
    
    8. 
    
  















    

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