L-Arginine untuk Heart Failure

Q: Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

Q: How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

D Penelitian Hanya penelitian awal yang ada (studi laboratorium, laporan kasus).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

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Kesimpulan

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

Review

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Humans (general)

animal_study

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …

Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo Efek: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported

In Vitro

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure Efek: reduced ROS and improved cell survival None

Populasi: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.

Dose: 10 mg/kg vs: None Outcome: anxiety Efek: None p < 0.05

Populasi: patients with anxiety

Other 1.0 weeks

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …

Dose: None vs: None Outcome: Nitric oxide modulation mediates the protective effect of … Efek: None p<0.05

Populasi: None

Review

Immunonutrition.

Dose: Glutamine, omega-3, antioxidants, arginine vs: None Outcome: Immune function and clinical outcomes Efek: None None

Populasi: Surgical, ICU, cancer, Crohn's disease patients

Key Statistics

Studi

150

Peserta

↔

Mixed

Peringkat

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 sitasi

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 sitasi

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other

Molecular medicine reports 2016 48 sitasi

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 sitasi

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Immunonutrition. Review

Current opinion in … 2005 22 sitasi

Arginine and cancer. Review

The Journal of … 2004 181 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

endothelialfunction:: 3,000-6,000 mg/day
bloodpressuresupport:: 6,000-10,000 mg/day divided BID-TID

Batas atas: Not formally established; GI discomfort common above 10,000 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)	--	Positive	--
astaxanthin	--	Positive	--
10 mg/kg	1.0 weeks	Positive	--
None	1.0 weeks	Mixed	--
Glutamine, omega-3, antioxidants, arginine	--	Positive	--
L-arginine	--	Mixed	--

Waktu terbaik diminum: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
⚠ Hypotension at high doses
⚠ Worsening of herpes simplex (arginine promotes viral replication)
⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

Interaksi yang Diketahui

● Antihypertensives (additive blood pressure lowering)
● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
● Nitrates (excessive vasodilation risk)
● Anticoagulants (may have mild antiplatelet effect)
● Potassium-sparing diuretics (arginine may increase potassium levels)

Asupan atas yang dapat ditoleransi: Not formally established; GI discomfort common above 10,000 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Bahan lain untuk Heart Failure

Coenzyme Q10 (CoQ10) B Hawthorn B Vitamin D C Taurine C PQQ (Pyrroloquinoline Quinone) D NMN (Nicotinamide Mononucleotide) D

L-Arginine untuk kondisi lain

Endothelial Dysfunction C

Kesimpulan Singkat

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Evidence Strength30%

Low confidence

Rincian Studi

RCT (0)Meta (0)Other (3)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Heart Failure

Pelajari Lebih Lanjut

References

[1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
[3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
[4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
[5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
[6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
[7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.

L-Arginine untuk Heart Failure

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Kesimpulan

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosis yang Umum Digunakan

Dosis yang Diteliti dalam Penelitian

Safety & Side Effects

Efek Samping yang Dilaporkan

Interaksi yang Diketahui

Frequently Asked Questions

Related Evidence

Bahan lain untuk Heart Failure

L-Arginine untuk kondisi lain

References