L-Arginine لـ Heart Failure

Q: Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

Q: How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

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الخلاصة

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

Review

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Humans (general)

animal_study

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …

Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) مقابل: Placebo التأثير: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported

In Vitro

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Dose: astaxanthin مقابل: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure التأثير: reduced ROS and improved cell survival None

المجتمع المدروس: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.

Dose: 10 mg/kg مقابل: None Outcome: anxiety التأثير: None p < 0.05

المجتمع المدروس: patients with anxiety

Other 1.0 weeks

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …

Dose: None مقابل: None Outcome: Nitric oxide modulation mediates the protective effect of … التأثير: None p<0.05

المجتمع المدروس: None

Review

Immunonutrition.

Dose: Glutamine, omega-3, antioxidants, arginine مقابل: None Outcome: Immune function and clinical outcomes التأثير: None None

المجتمع المدروس: Surgical, ICU, cancer, Crohn's disease patients

Key Statistics

الدراسات

150

المشاركون

↔

Mixed

التقييم

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 اقتباسات

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 اقتباسات

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other

Molecular medicine reports 2016 48 اقتباسات

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 اقتباسات

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Immunonutrition. Review

Current opinion in … 2005 22 اقتباسات

Arginine and cancer. Review

The Journal of … 2004 181 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

endothelialfunction:: 3,000-6,000 mg/day
bloodpressuresupport:: 6,000-10,000 mg/day divided BID-TID

الحد الأعلى: Not formally established; GI discomfort common above 10,000 mg/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Mixed	--
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)	--	Positive	--
astaxanthin	--	Positive	--
10 mg/kg	1.0 weeks	Positive	--
None	1.0 weeks	Mixed	--
Glutamine, omega-3, antioxidants, arginine	--	Positive	--
L-arginine	--	Mixed	--

أفضل وقت للتناول: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
⚠ Hypotension at high doses
⚠ Worsening of herpes simplex (arginine promotes viral replication)
⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

التفاعلات المعروفة

● Antihypertensives (additive blood pressure lowering)
● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
● Nitrates (excessive vasodilation risk)
● Anticoagulants (may have mild antiplatelet effect)
● Potassium-sparing diuretics (arginine may increase potassium levels)

الحد الأقصى المسموح به: Not formally established; GI discomfort common above 10,000 mg/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

مكونات أخرى لـ Heart Failure

Coenzyme Q10 (CoQ10) B Hawthorn B Vitamin D C Taurine C PQQ (Pyrroloquinoline Quinone) D NMN (Nicotinamide Mononucleotide) D

L-Arginine لحالات أخرى

Endothelial Dysfunction C

الخلاصة السريعة

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Evidence Strength30%

Low confidence

تفصيل الدراسات

RCT (0)Meta (0)Other (3)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Heart Failure

اعرف المزيد

References

[1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
[3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
[4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
[5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
[6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
[7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed

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L-Arginine لـ Heart Failure

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الخلاصة

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

الجرعات الشائعة

الجرعات المدروسة في الأبحاث

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

التفاعلات المعروفة

Frequently Asked Questions

Related Evidence

مكونات أخرى لـ Heart Failure

L-Arginine لحالات أخرى

References