L-Arginine के लिए Heart Failure

Q: Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

Q: How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

D अनुसंधान केवल प्रारंभिक शोध उपलब्ध है (प्रयोगशाला अध्ययन, केस रिपोर्ट)।

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

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निष्कर्ष

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

Review

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: Humans (general)

animal_study

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …

Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) बनाम: Placebo प्रभाव: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported

In Vitro

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Dose: astaxanthin बनाम: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure प्रभाव: reduced ROS and improved cell survival None

जनसंख्या: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.

Dose: 10 mg/kg बनाम: None Outcome: anxiety प्रभाव: None p < 0.05

जनसंख्या: patients with anxiety

Other 1.0 weeks

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …

Dose: None बनाम: None Outcome: Nitric oxide modulation mediates the protective effect of … प्रभाव: None p<0.05

जनसंख्या: None

Review

Immunonutrition.

Dose: Glutamine, omega-3, antioxidants, arginine बनाम: None Outcome: Immune function and clinical outcomes प्रभाव: None None

जनसंख्या: Surgical, ICU, cancer, Crohn's disease patients

Key Statistics

अध्ययन

150

प्रतिभागी

↔

Mixed

ग्रेड

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 उद्धरण

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 उद्धरण

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other

Molecular medicine reports 2016 48 उद्धरण

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 उद्धरण

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Immunonutrition. Review

Current opinion in … 2005 22 उद्धरण

Arginine and cancer. Review

The Journal of … 2004 181 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

endothelialfunction:: 3,000-6,000 mg/day
bloodpressuresupport:: 6,000-10,000 mg/day divided BID-TID

अधिकतम सीमा: Not formally established; GI discomfort common above 10,000 mg/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Mixed	--
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)	--	Positive	--
astaxanthin	--	Positive	--
10 mg/kg	1.0 weeks	Positive	--
None	1.0 weeks	Mixed	--
Glutamine, omega-3, antioxidants, arginine	--	Positive	--
L-arginine	--	Mixed	--

सेवन का सर्वोत्तम समय: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
⚠ Hypotension at high doses
⚠ Worsening of herpes simplex (arginine promotes viral replication)
⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

ज्ञात अंतःक्रियाएँ

● Antihypertensives (additive blood pressure lowering)
● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
● Nitrates (excessive vasodilation risk)
● Anticoagulants (may have mild antiplatelet effect)
● Potassium-sparing diuretics (arginine may increase potassium levels)

सहनीय अधिकतम सेवन: Not formally established; GI discomfort common above 10,000 mg/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

इसके लिए अन्य सामग्री Heart Failure

Coenzyme Q10 (CoQ10) B Hawthorn B Vitamin D C Taurine C PQQ (Pyrroloquinoline Quinone) D NMN (Nicotinamide Mononucleotide) D

L-Arginine अन्य स्वास्थ्य स्थितियों के लिए

Endothelial Dysfunction C

संक्षिप्त निष्कर्ष

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Evidence Strength30%

Low confidence

अध्ययन विश्लेषण

RCT (0)Meta (0)Other (3)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Heart Failure

अधिक जानें

References

[1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
[3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
[4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
[5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
[6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
[7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

L-Arginine के लिए Heart Failure

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निष्कर्ष

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

सामान्य रूप से उपयोग की जाने वाली खुराकें

अनुसंधान में अध्ययन की गई खुराकें

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

ज्ञात अंतःक्रियाएँ

Frequently Asked Questions

Related Evidence

इसके लिए अन्य सामग्री Heart Failure

L-Arginine अन्य स्वास्थ्य स्थितियों के लिए

References