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L-Arginine के लिए Endothelial Dysfunction

C साक्ष्य की तुलना करें छोटे अध्ययनों से सीमित साक्ष्य उपलब्ध हैं, लेकिन कुछ सकारात्मक संकेत मौजूद हैं।

Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

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            C

        

        

            
निष्कर्ष

            
            
Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    animal_study
                
                
                
                
            

            
                Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
            
            

                
                Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
                
                
                बनाम: Placebo
                
                
                
                प्रभाव: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in
                
                
                not_reported
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
11

        
अध्ययन

    

    

        
600

        
प्रतिभागी

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
ग्रेड

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2021
                        
                        18 उद्धरण
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
सामान्य रूप से उपयोग की जाने वाली खुराकें

                

                    
                    

                        
endothelialfunction:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
6,000-10,000 mg/day divided BID-TID

                    

                    
                

                
                

                    अधिकतम सीमा: Not formally established; GI discomfort common above 10,000 mg/day
                

                
            

            

            
            

                
अनुसंधान में अध्ययन की गई खुराकें

                

                    

                        
                            

                                खुराक
                                अवधि
                                प्रभाव
                                N
                            

                        
                        
                            
                            

                                NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                सेवन का सर्वोत्तम समय: On empty stomach for best absorption; divide doses throughout the day
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
रिपोर्ट किए गए दुष्प्रभाव

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea, bloating)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hypotension at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Worsening of herpes simplex (arginine promotes viral replication)
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential harm in acute post-MI patients (VINTAGE MI concern)
                        
    • 
                        
                    

                

                

                
                

                    
ज्ञात अंतःक्रियाएँ

                    
    
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (sildenafil — excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Nitrates (excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may have mild antiplatelet effect)
                        
    • 
                        
                        
  • 
                            ●
                            Potassium-sparing diuretics (arginine may increase potassium levels)
                        
    • 
                        
                    

                

                

                
                

                    

                        सहनीय अधिकतम सेवन: Not formally established; GI discomfort common above 10,000 mg/day
                    

                

                
            

            

                कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Arginine help with Endothelial Dysfunction?
            
        
        

            Based on 11 studies with 600 participants, there is limited but promising evidence that L-Arginine may support Endothelial Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Arginine should I take for Endothelial Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Arginine?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Arginine and Endothelial Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 11 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
इसके लिए अन्य सामग्री Endothelial Dysfunction

                    

                        
                        
                            Cocoa Flavanols
                            A

                        
                        
                        
                            Grape Seed Extract
                            C

                        
                        
                        
                            Astaxanthin
                            D

                        
                        
                    

                

                

                
                

                    
L-Arginine अन्य स्वास्थ्य स्थितियों के लिए

                    

                        
                        
                            Heart Failure
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Priya Pathak et al..
      J Ethnopharmacol.
      2021.
      Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
      doi:10.1016/j.jep.2021.114296
      PubMed
    
    2. 
    
  















    

        FDA अस्वीकरण:
        इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।