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L-Arginine
L-Arginine

amino_acid

别名: Arginine, L-Arg, Arginine Hydrochloride, Arginine Alpha-Ketoglutarate

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About





            

                
L-Arginine is the direct substrate for endothelial nitric oxide synthase (eNOS), the enzyme that produces nitric oxide — the primary endogenous vasodilator. A 2011 meta-analysis of 11 RCTs found L-arginine reduced systolic blood pressure by 5.39 mmHg. However, the VINTAGE MI trial was terminated early due to a trend toward increased mortality in post-MI patients, so L-arginine should be avoided in acute coronary syndromes.

            

        

        

        
        
        

            

  
How It Works





            

                
Direct substrate for endothelial nitric oxide synthase (eNOS), which produces nitric oxide (NO) — the primary endogenous vasodilator; NO activates soluble guanylate cyclase increasing cGMP causing smooth muscle relaxation; also inhibits platelet adhesion and aggregation; reduces endothelin-1 expression.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Endothelial Dysfunction
                                    
                                
                                
                                    C

                                
                                
                                    11
                                
                                
                                    600
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Heart Failure
                                    
                                
                                
                                    D

                                
                                
                                    3
                                
                                
                                    150
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Gastrointestinal discomfort (nausea, diarrhea, bloating)
                
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                    Hypotension at high doses
                
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                    Worsening of herpes simplex (arginine promotes viral replication)
                
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                    Potential harm in acute post-MI patients (VINTAGE MI concern)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Antihypertensives (additive blood pressure lowering)
                
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                    PDE5 inhibitors (sildenafil — excessive vasodilation risk)
                
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                    Nitrates (excessive vasodilation risk)
                
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                    Anticoagulants (may have mild antiplatelet effect)
                
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                    Potassium-sparing diuretics (arginine may increase potassium levels)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    L-Citrulline
                    
                
                
                
                    Taurine
                    
                
                
                
                    Nattokinase
                    
                
                
            

        

        
    


    
    












    

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