L-Arginine 用于 心力衰竭
D 研究 目前仅存在初步研究（实验室研究、病例报告）。Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
结论
Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
Key Study Findings
研究人群: Preeclamptic rat model and HUVECs
研究人群: patients with anxiety
研究人群: Surgical, ICU, cancer, Crohn's disease patients
Key Statistics
3
研究数量
150
受试者
Mixed
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- endothelialfunction:
- 3,000-6,000 mg/day
- bloodpressuresupport:
- 6,000-10,000 mg/day divided BID-TID
上限： Not formally established; GI discomfort common above 10,000 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) | -- | Positive | -- |
| astaxanthin | -- | Positive | -- |
| 10 mg/kg | 1.0 weeks | Positive | -- |
| Glutamine, omega-3, antioxidants, arginine | -- | Positive | -- |
| L-arginine | -- | Mixed | -- |
最佳服用时间： On empty stomach for best absorption; divide doses throughout the day
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Hypotension at high doses
- ⚠ Worsening of herpes simplex (arginine promotes viral replication)
- ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)
已知相互作用
- ● Antihypertensives (additive blood pressure lowering)
- ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
- ● Nitrates (excessive vasodilation risk)
- ● Anticoagulants (may have mild antiplatelet effect)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
可耐受最高摄入量： Not formally established; GI discomfort common above 10,000 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does L-Arginine help with 心力衰竭?
How much L-Arginine should I take for 心力衰竭?
Are there side effects of L-Arginine?
How strong is the evidence for L-Arginine and 心力衰竭?
Related Evidence
其他成分用于 心力衰竭
L-Arginine 用于其他健康状况
References
- [1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
- [3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
- [4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
- [5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
- [6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
- [7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed
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