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L-Arginine 用于 内皮功能障碍

C 证据 来自小型研究的证据有限，但存在一些积极信号。

Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

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            C

        

        

            
结论

            
            
Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    animal_study
                
                
                
                
            

            
                Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
            
            

                
                Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
                
                
                vs: Placebo
                
                
                
                效果: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in
                
                
                not_reported
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
11

        
研究数量

    

    

        
600

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of ethnopharmacology
                        2021
                        
                        18 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
endothelialfunction:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
6,000-10,000 mg/day divided BID-TID

                    

                    
                

                
                

                    上限： Not formally established; GI discomfort common above 10,000 mg/day
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： On empty stomach for best absorption; divide doses throughout the day
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea, bloating)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hypotension at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Worsening of herpes simplex (arginine promotes viral replication)
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential harm in acute post-MI patients (VINTAGE MI concern)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (sildenafil — excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Nitrates (excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may have mild antiplatelet effect)
                        
    • 
                        
                        
  • 
                            ●
                            Potassium-sparing diuretics (arginine may increase potassium levels)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not formally established; GI discomfort common above 10,000 mg/day
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Arginine help with 内皮功能障碍?
            
        
        

            Based on 11 studies with 600 participants, there is limited but promising evidence that L-Arginine may support 内皮功能障碍 management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Arginine should I take for 内皮功能障碍?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Arginine?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Arginine and 内皮功能障碍?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 11 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
L-Arginine 用于其他健康状况

                    

                        
                        
                            心力衰竭
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Priya Pathak et al..
      J Ethnopharmacol.
      2021.
      Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
      doi:10.1016/j.jep.2021.114296
      PubMed
    
    2. 
    
  















    

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