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Grape Seed Extract 用于 Endothelial Dysfunction

C

Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

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            C

        

        

            
结论

            
            
Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
6

        
研究数量

    

    

        
350

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
100-300 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
150-300 mg/day standardized to 95% OPCs

                    

                    
                

                
                

                    上限： Not formally established; up to 600 mg/day used in clinical trials
                

                
            

            

            

            
            

                最佳服用时间： With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild headache (rare)
                        
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  • 
                            ⚠
                            Dizziness (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea (rare)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
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  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
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  • 
                            ●
                            Iron supplements (tannins may reduce iron absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not formally established; up to 600 mg/day used in clinical trials
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Grape Seed Extract help with Endothelial Dysfunction?
            
        
        

            Based on 6 studies with 350 participants, there is limited but promising evidence that Grape Seed Extract may support Endothelial Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Grape Seed Extract should I take for Endothelial Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 100-300 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Grape Seed Extract?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Grape Seed Extract and Endothelial Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
其他成分用于 Endothelial Dysfunction

                    

                        
                        
                            Cocoa Flavanols
                            A

                        
                        
                        
                            L-Arginine
                            C

                        
                        
                        
                            Astaxanthin
                            D

                        
                        
                    

                

                

                
                

                    
Grape Seed Extract 用于其他健康状况

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

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