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Grape Seed Extract for Endothelial Dysfunction

C

Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

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The Bottom Line

            
            
Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studies

    

    

        
350

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
100-300 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
150-300 mg/day standardized to 95% OPCs

                    

                    
                

                
                

                    Upper limit: Not formally established; up to 600 mg/day used in clinical trials
                

                
            

            

            

            
            

                Best taken: With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Generally well-tolerated
                        
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                            ⚠
                            Mild headache (rare)
                        
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                            ⚠
                            Dizziness (rare)
                        
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                            ⚠
                            Nausea (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
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                            ●
                            Anticoagulants (may increase bleeding risk)
                        
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                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
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                            ●
                            Iron supplements (tannins may reduce iron absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established; up to 600 mg/day used in clinical trials
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Grape Seed Extract help with Endothelial Dysfunction?
            
        
        

            Based on 6 studies with 350 participants, there is limited but promising evidence that Grape Seed Extract may support Endothelial Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Grape Seed Extract should I take for Endothelial Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 100-300 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Grape Seed Extract?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Grape Seed Extract and Endothelial Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Endothelial Dysfunction

                    

                        
                        
                            Cocoa Flavanols
                            A

                        
                        
                        
                            L-Arginine
                            C

                        
                        
                        
                            Astaxanthin
                            D

                        
                        
                    

                

                

                
                

                    
Grape Seed Extract for other conditions

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.