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Grape Seed Extract pour Endothelial Dysfunction

C Preuves Preuves limitées issues de petites études, mais certains signaux positifs existent.

Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

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            C

        

        

            
En conclusion

            
            
Improved FMD in several small RCTs. OPCs have 20-50x antioxidant capacity vs. vitamins C and E. Larger trials with clinical endpoints are needed.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                8 weeks
                
                
                Double-blind
                
            

            
                Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers …
            
            

                
                Dose: 180 mg/d
                
                
                vs: None
                
                
                Outcome: lipid levels
                
                
                Effet: None
                
                
                p < 0.001
                
            

            
            
Population: Patients with dyslipidemia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Études

    

    

        
350

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Note

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2023
                        
                        8 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Posologies couramment utilisées

                

                    
                    

                        
general:

                        
100-300 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
150-300 mg/day standardized to 95% OPCs

                    

                    
                

                
                

                    Limite supérieure : Not formally established; up to 600 mg/day used in clinical trials
                

                
            

            

            
            

                
Posologies étudiées dans la recherche

                

                    

                        
                            

                                Posologie
                                Durée
                                Effet
                                N
                            

                        
                        
                            
                            

                                180 mg/d
                                8 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Moment optimal de prise : With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effets indésirables signalés

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild headache (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Dizziness (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Interactions connues

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (tannins may reduce iron absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Apport maximal tolérable : Not formally established; up to 600 mg/day used in clinical trials
                    

                

                
            

            

                Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Grape Seed Extract help with Endothelial Dysfunction?
            
        
        

            Based on 6 studies with 350 participants, there is limited but promising evidence that Grape Seed Extract may support Endothelial Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Grape Seed Extract should I take for Endothelial Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 100-300 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Grape Seed Extract?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Grape Seed Extract and Endothelial Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Autres ingrédients pour Endothelial Dysfunction

                    

                        
                        
                            Cocoa Flavanols
                            A

                        
                        
                        
                            L-Arginine
                            C

                        
                        
                        
                            Astaxanthin
                            D

                        
                        
                    

                

                

                
                

                    
Grape Seed Extract pour d'autres pathologies

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Nicholas Angelopoulos et al..
      Nutrients.
      2023.
      Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with …
      doi:10.3390/nu15122682
      PubMed
    
    2. 
    
  















    

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        Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.