Folate (Vitamin B9) para Coronary Artery Disease (CAD)

Q: Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C Evidências Evidência limitada de estudos de pequena dimensão, mas existem alguns sinais positivos.

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dfolate\u0026condition\u003Dcoronary\u002Dartery\u002Ddisease'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Conclusão

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None vs: Placebo Efeito: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None vs: None Outcome: Mortality Efeito: None None

População: None

Review

Folic acid and diseases - supplement it or not?

Dose: None vs: Placebo Efeito: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins vs: None Outcome: Stroke prevention Efeito: None None

População: Stroke-risk population

Key Statistics

Estudos

40000

Participantes

↔

Mixed

Nota

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 citações

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 citações

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 citações

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

Limite superior: 1,000 mcg/day folic acid from supplements

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

Melhor horário: With or without food; consistent daily timing preferred

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

Interações Conhecidas

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

Ingestão máxima tolerável: 1,000 mcg/day folic acid from supplements

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

Outros ingredientes para Coronary Artery Disease (CAD)

Omega-3 Fatty Acids (EPA/DHA) B Magnesium C Selenium C

Folate (Vitamin B9) para outras condições

Elevated Homocysteine (Hyperhomocysteinemia) B

Veredito Rápido

Evidence Strength52%

Moderate confidence

Detalhamento dos Estudos

RCT (0)Meta (1)Other (9)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Coronary Artery Disease (CAD)

Saiba Mais

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.