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Folate (Vitamin B9) untuk Coronary Artery Disease (CAD)

C

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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Kesimpulan

            
            
CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
10

        
Studi

    

    

        
40000

        
Peserta

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
Peringkat

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
400 mcg DFE/day

                    

                    
                    

                        
homocysteinereduction:

                        
400-800 mcg/day folic acid (with B12 and B6)

                    

                    
                

                
                

                    Batas atas: 1,000 mcg/day folic acid from supplements
                

                
            

            

            

            
            

                Waktu terbaik diminum: With or without food; consistent daily timing preferred
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated
                        
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  • 
                            ⚠
                            May mask vitamin B12 deficiency at high doses
                        
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  • 
                            ⚠
                            Rare: mild gastrointestinal discomfort
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Methotrexate (folate may reduce efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
                        
    • 
                        
                        
  • 
                            ●
                            Vitamin B12 (co-supplementation recommended for homocysteine reduction)
                        
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                        Asupan atas yang dapat ditoleransi: 1,000 mcg/day folic acid from supplements
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Folate (Vitamin B9)?
            
        
        

            Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Bahan lain untuk Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Magnesium
                            C

                        
                        
                        
                            Selenium
                            C

                        
                        
                    

                

                

                
                

                    
Folate (Vitamin B9) untuk kondisi lain

                    

                        
                        
                            Elevated Homocysteine (Hyperhomocysteinemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        Penafian FDA:
        Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.