Folate (Vitamin B9) 관련 관상동맥질환(CAD)

Q: Does Folate (Vitamin B9) help with 관상동맥질환(CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support 관상동맥질환(CAD) management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for 관상동맥질환(CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and 관상동맥질환(CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C 근거 소규모 연구에서의 근거는 제한적이지만, 일부 긍정적인 신호가 존재합니다.

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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결론

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None vs: Placebo 효과: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None vs: None Outcome: Mortality 효과: None None

대상 집단: None

Review

Folic acid and diseases - supplement it or not?

Dose: None vs: Placebo 효과: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins vs: None Outcome: Stroke prevention 효과: None None

대상 집단: Stroke-risk population

Key Statistics

연구

40000

참여자

↔

Mixed

등급

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 인용

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 인용

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 인용

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

상한량: 1,000 mcg/day folic acid from supplements

연구에서 사용된 용량

용량	기간	효과	N
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

권장 복용 시간: With or without food; consistent daily timing preferred

Safety & Side Effects

보고된 부작용

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

알려진 상호작용

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

일일 최대 섭취 허용량: 1,000 mcg/day folic acid from supplements

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does Folate (Vitamin B9) help with 관상동맥질환(CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support 관상동맥질환(CAD) management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for 관상동맥질환(CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and 관상동맥질환(CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

Folate (Vitamin B9) 다른 건강 상태에 대한 근거

고호모시스테인혈증 B

한눈에 보기

Evidence Strength52%

Moderate confidence

연구 분석

RCT (0)Meta (1)Other (9)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 관상동맥질환(CAD)

자세히 알아보기

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.