Folate (Vitamin B9) pour Coronary Artery Disease (CAD)

Q: Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C Preuves Preuves limitées issues de petites études, mais certains signaux positifs existent.

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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En conclusion

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None vs: Placebo Effet: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None vs: None Outcome: Mortality Effet: None None

Population: None

Review

Folic acid and diseases - supplement it or not?

Dose: None vs: Placebo Effet: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins vs: None Outcome: Stroke prevention Effet: None None

Population: Stroke-risk population

Key Statistics

Études

40000

Participants

↔

Mixed

Note

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 citations

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 citations

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 citations

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

Limite supérieure : 1,000 mcg/day folic acid from supplements

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

Moment optimal de prise : With or without food; consistent daily timing preferred

Safety & Side Effects

Effets indésirables signalés

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

Interactions connues

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

Apport maximal tolérable : 1,000 mcg/day folic acid from supplements

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

Autres ingrédients pour Coronary Artery Disease (CAD)

Omega-3 Fatty Acids (EPA/DHA) B Magnesium C Selenium C

Folate (Vitamin B9) pour d'autres pathologies

Elevated Homocysteine (Hyperhomocysteinemia) B

Verdict rapide

Evidence Strength52%

Moderate confidence

Synthèse des études

RCT (0)Meta (1)Other (9)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Coronary Artery Disease (CAD)

En savoir plus

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.