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Magnesium for Coronary Artery Disease (CAD)

C

Prospective cohorts show 22% lower CHD risk with higher magnesium intake. Interventional data is limited. Mechanistic rationale is strong (anti-inflammatory, anti-arrhythmic effects).

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The Bottom Line

            
            
Prospective cohorts show 22% lower CHD risk with higher magnesium intake. Interventional data is limited. Mechanistic rationale is strong (anti-inflammatory, anti-arrhythmic effects).

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studies

    

    

        
350

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
310-420 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
300-500 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
300-400 mg/day elemental magnesium

                    

                    
                

                
                

                    Upper limit: 350 mg/day from supplements only (no UL for food magnesium)
                

                
            

            

            

            
            

                Best taken: With meals to reduce GI side effects; evening dosing may support sleep
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Diarrhea (especially magnesium oxide and citrate)
                        
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                            ⚠
                            Nausea
                        
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                            ⚠
                            Abdominal cramping
                        
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                            ⚠
                            Excessive doses may cause hypotension or cardiac depression
                        
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Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Bisphosphonates (reduced absorption — separate by 2 hours)
                        
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                            ●
                            Antibiotics (tetracyclines, fluoroquinolones — separate by 2-4 hours)
                        
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                            Diuretics (thiazides reduce, loop diuretics increase magnesium loss)
                        
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                            ●
                            Proton pump inhibitors (long-term use may cause hypomagnesemia)
                        
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                        Tolerable upper intake: 350 mg/day from supplements only (no UL for food magnesium)
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Magnesium help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 5 studies with 350 participants, there is limited but promising evidence that Magnesium may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Magnesium should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 310-420 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Magnesium?
            
        
        

            Reported side effects may include Diarrhea (especially magnesium oxide and citrate), Nausea, Abdominal cramping, Excessive doses may cause hypotension or cardiac depression. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Magnesium and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Folate (Vitamin B9)
                            C

                        
                        
                        
                            Selenium
                            C

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.