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Selenium for Coronary Artery Disease (CAD)

C Some Evidence Limited evidence from small studies, but some positive signals exist.

SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

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            C

        

        

            
The Bottom Line

            
            
SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Controlled Clinical Trial
                
                
                
                
            

            
                Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: antioxidant status
                
                
                Effect: None
                
                
                p=0.001
                
            

            
            
Population: patients with depression

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: blood pressure
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: hypertension patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studies

    

    

        
10000

        
Participants

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2011
                        
                        396 citations
                        
                    

                

                
                

                    

                        
                            Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Neuro endocrinology letters
                        2011
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
55 mcg/day

                    

                    
                    

                        
cardiovascularantioxidant:

                        
100-200 mcg/day

                    

                    
                

                
                

                    Upper limit: 400 mcg/day (risk of selenosis above this level)
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort at moderate-high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased type 2 diabetes risk at high supplemental doses
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Cisplatin and other chemotherapy drugs (may affect efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Statins (may enhance antioxidant effects)
                        
    • 
                        
                        
  • 
                            ●
                            CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: 400 mcg/day (risk of selenosis above this level)
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Selenium help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 5 studies with 10,000 participants, there is limited but promising evidence that Selenium may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Selenium should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Selenium?
            
        
        

            Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Selenium and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 10,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Other ingredients for Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Folate (Vitamin B9)
                            C

                        
                        
                        
                            Magnesium
                            C

                        
                        
                    

                

                

                
                

                    
Selenium for other conditions

                    

                        
                        
                            Oxidative Stress (Cardiovascular)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Mark C Houston.
      J Clin Hypertens (Greenwich).
      2011.
      Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
      doi:10.1111/j.1751-7176.2011.00489.x
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Michael Maes et al..
      Neuro Endocrinol Lett.
      2011.
      Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
      
      PubMed
    
    3. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.