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Selenium für Coronary Artery Disease (CAD)

C Evidenz Begrenzte Evidenz aus kleinen Studien, aber es gibt einige positive Signale.

SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

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            C

        

        

            
Fazit

            
            
SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Controlled Clinical Trial
                
                
                
                
            

            
                Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / …
            
            

                
                Dose: None
                
                
                vs.: None
                
                
                Outcome: antioxidant status
                
                
                Wirkung: None
                
                
                p=0.001
                
            

            
            
Population: patients with depression

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
            
            

                
                Dose: None
                
                
                vs.: None
                
                
                Outcome: blood pressure
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: hypertension patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studien

    

    

        
10000

        
Teilnehmer

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
Bewertung

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2011
                        
                        396 Zitierungen
                        
                    

                

                
                

                    

                        
                            Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Neuro endocrinology letters
                        2011
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Übliche Dosierungen

                

                    
                    

                        
general:

                        
55 mcg/day

                    

                    
                    

                        
cardiovascularantioxidant:

                        
100-200 mcg/day

                    

                    
                

                
                

                    Obergrenze: 400 mcg/day (risk of selenosis above this level)
                

                
            

            

            
            

                
In der Forschung untersuchte Dosierungen

                

                    

                        
                            

                                Dosierung
                                Dauer
                                Wirkung
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Beste Einnahmezeit: With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Gemeldete Nebenwirkungen

                    
    
                        
                        
  • 
                            ⚠
                            Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort at moderate-high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased type 2 diabetes risk at high supplemental doses
                        
    • 
                        
                    

                

                

                
                

                    
Bekannte Wechselwirkungen

                    
    
                        
                        
  • 
                            ●
                            Cisplatin and other chemotherapy drugs (may affect efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Statins (may enhance antioxidant effects)
                        
    • 
                        
                        
  • 
                            ●
                            CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerierbare Höchstaufnahmemenge: 400 mcg/day (risk of selenosis above this level)
                    

                

                
            

            

                Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Selenium help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 5 studies with 10,000 participants, there is limited but promising evidence that Selenium may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Selenium should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Selenium?
            
        
        

            Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Selenium and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 10,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Andere Inhaltsstoffe für Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Folate (Vitamin B9)
                            C

                        
                        
                        
                            Magnesium
                            C

                        
                        
                    

                

                

                
                

                    
Selenium für andere Beschwerden

                    

                        
                        
                            Oxidative Stress (Cardiovascular)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Mark C Houston.
      J Clin Hypertens (Greenwich).
      2011.
      Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
      doi:10.1111/j.1751-7176.2011.00489.x
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Michael Maes et al..
      Neuro Endocrinol Lett.
      2011.
      Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
      
      PubMed
    
    3. 
    
  















    

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