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Selenium ： Coronary Artery Disease (CAD)

C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

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            C

        

        

            
結論

            
            
SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Controlled Clinical Trial
                
                
                
                
            

            
                Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: antioxidant status
                
                
                効果: None
                
                
                p=0.001
                
            

            
            
対象集団: patients with depression

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: blood pressure
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: hypertension patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
研究数

    

    

        
10000

        
参加者数

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2011
                        
                        396 件の引用
                        
                    

                

                
                

                    

                        
                            Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Neuro endocrinology letters
                        2011
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
55 mcg/day

                    

                    
                    

                        
cardiovascularantioxidant:

                        
100-200 mcg/day

                    

                    
                

                
                

                    上限量： 400 mcg/day (risk of selenosis above this level)
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort at moderate-high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased type 2 diabetes risk at high supplemental doses
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Cisplatin and other chemotherapy drugs (may affect efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Statins (may enhance antioxidant effects)
                        
    • 
                        
                        
  • 
                            ●
                            CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 400 mcg/day (risk of selenosis above this level)
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Selenium help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 5 studies with 10,000 participants, there is limited but promising evidence that Selenium may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Selenium should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Selenium?
            
        
        

            Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Selenium and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 10,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
に関する他の成分： Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Folate (Vitamin B9)
                            C

                        
                        
                        
                            Magnesium
                            C

                        
                        
                    

                

                

                
                

                    
Selenium 他の症状・状態について

                    

                        
                        
                            Oxidative Stress (Cardiovascular)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Mark C Houston.
      J Clin Hypertens (Greenwich).
      2011.
      Role of mercury toxicity in hypertension, cardiovascular disease, and stroke.
      doi:10.1111/j.1751-7176.2011.00489.x
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Michael Maes et al..
      Neuro Endocrinol Lett.
      2011.
      Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway …
      
      PubMed
    
    3. 
    
  















    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。