Selenium ： Oxidative Stress (Cardiovascular)
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
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B
結論
KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
Key Study Findings
animal study
Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …
Dose: zinc and/or selenium supplementation; doses not specified in abstract
vs: Placebo
効果: None
None
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A …
Dose: None
vs: None
Outcome: MASLD treatment and prevention
効果: None
None
対象集団: Patients with metabolic steatotic liver disease (review)
Review
Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: People with depression
preclinical animal study with human correlational observation
Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment.
Dose: oral administration; specific dose not reported in abstract
vs: Placebo
効果: None
None
Review
The Role of Various Types of Diets in the Treatments of Depressive Disorders.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Adults with depression
prospective controlled study
n=30
Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …
Dose: None
vs: Placebo
効果: None
None
Key Statistics
3
研究数
600
参加者数
↑
Positive
B
グレード
Referenced Papers
Environment international
2026
Biomaterials
2025
8 件の引用
Nutrients
2025
3 件の引用
Cutaneous and ocular …
2025
1 件の引用
Medicina (Kaunas, Lithuania)
2025
1 件の引用
Biogerontology
2025
International journal of …
2025
Molecules (Basel, Switzerland)
2024
13 件の引用
Food & function
2024
6 件の引用
Journal of dairy …
2024
4 件の引用
Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis.
Meta-Analysis
Biological trace element …
2024
2 件の引用
Nutrients
2023
75 件の引用
International journal of …
2023
45 件の引用
BMC endocrine disorders
2023
25 件の引用
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Review
Metabolites
2023
13 件の引用
Journal of animal …
2023
11 件の引用
Animals : an …
2023
7 件の引用
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Other
Antioxidants (Basel, Switzerland)
2023
5 件の引用
Antioxidants (Basel, Switzerland)
2022
13 件の引用
Animal bioscience
2022
9 件の引用
Journal of inflammation …
2021
34 件の引用
Biological trace element …
2021
18 件の引用
Nutricion hospitalaria
2021
10 件の引用
Redox biology
2020
184 件の引用
Environmental science and …
2020
79 件の引用
Molecules (Basel, Switzerland)
2019
472 件の引用
British journal of …
2019
14 件の引用
Advances in clinical …
2018
200 件の引用
Nutricion hospitalaria
2018
32 件の引用
JAMA neurology
2017
258 件の引用
Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium.
Review
Placenta
2016
23 件の引用
Biological trace element …
2015
1 件の引用
Free radical biology …
2013
208 件の引用
Molecular nutrition & …
2012
65 件の引用
Biological trace element …
2012
31 件の引用
Alcoholism, clinical and …
2012
19 件の引用
Journal of clinical …
2011
396 件の引用
Nutrition and cancer
2011
19 件の引用
Nutrition in clinical …
2008
125 件の引用
The American journal …
2000
472 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 55 mcg/day
- cardiovascularantioxidant:
- 100-200 mcg/day
上限量： 400 mcg/day (risk of selenosis above this level)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| zinc and/or selenium supplementation; doses not specified in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| oral administration; specific dose not reported in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | 30 |
| None | -- | Negative | 2065 |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
- ⚠ GI discomfort at moderate-high doses
- ⚠ Potential increased type 2 diabetes risk at high supplemental doses
既知の相互作用
- ● Cisplatin and other chemotherapy drugs (may affect efficacy)
- ● Statins (may enhance antioxidant effects)
- ● CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
耐容上限摂取量： 400 mcg/day (risk of selenosis above this level)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Selenium help with Oxidative Stress (Cardiovascular)?
Based on 3 studies with 600 participants, there is moderate evidence from clinical studies that Selenium may support Oxidative Stress (Cardiovascular) management. Our evidence grade is B (Good Evidence).
How much Selenium should I take for Oxidative Stress (Cardiovascular)?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Selenium?
Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Selenium and Oxidative Stress (Cardiovascular)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Oxidative Stress (Cardiovascular)
Selenium 他の症状・状態について
References
- [1] Jing Ma et al.. Environ Int. 2026. Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights from multiomics analysis. doi:10.1016/j.envint.2025.109975 PubMed
- [2] Yang Yu et al.. Biomaterials. 2025. Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment. doi:10.1016/j.biomaterials.2024.122863 PubMed
- [3] Chuanming Liu et al.. Nutrients. 2025. Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review. doi:10.3390/nu17152484 PubMed
- [4] Deniz Duman Günsay et al.. Cutan Ocul Toxicol. 2025. Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and evaluation of their relationship with … doi:10.1080/15569527.2025.2511723 PubMed
- [5] Anna Lis et al.. Medicina (Kaunas). 2025. The Role of Various Types of Diets in the Treatments of Depressive Disorders. doi:10.3390/medicina61101737 PubMed
- [6] Laura Cianfruglia et al.. Biogerontology. 2025. Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. doi:10.1007/s10522-025-10288-x PubMed
- [7] Zuzanna Majewska et al.. Int J Mol Sci. 2025. Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review. doi:10.3390/ijms26146637 PubMed
- [8] Bianca Sânziana Daraban et al.. Molecules. 2024. Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems. doi:10.3390/molecules29174056 PubMed
- [9] Huijuan Wang et al.. Food Funct. 2024. Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut … doi:10.1039/d4fo02598a PubMed
- [10] Hannah Carlson et al.. J Dairy Sci. 2024. Effect of parenteral micronutrient supplementation at birth on immunity, growth, and health in preweaning dairy heifers. doi:10.3168/jds.2023-24292 PubMed
- [11] Mehrab Rahmani et al.. Biol Trace Elem Res. 2024. Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis. doi:10.1007/s12011-023-04026-y PubMed
- [12] Vicente Javier Clemente-Suárez et al.. Nutrients. 2023. Antioxidants and Sports Performance. doi:10.3390/nu15102371 PubMed
- [13] Davide Decandia et al.. Int J Mol Sci. 2023. Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer's Disease Animal Models of Lipopolysaccharide-Induced Inflammation. doi:10.3390/ijms24065921 PubMed
- [14] Junde Zhao et al.. BMC Endocr Disord. 2023. Effects of selenium supplementation on Polycystic Ovarian Syndrome: a systematic review and meta-analysis on randomized clinical trials. doi:10.1186/s12902-023-01286-6 PubMed
- [15] Emily Knight et al.. Metabolites. 2023. The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment. doi:10.3390/metabo13030438 PubMed
- [16] Hyun Woo Kim et al.. J Anim Sci Technol. 2023. Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress. doi:10.5187/jast.2023.e22 PubMed
- [17] Huanbin Wang et al.. Animals (Basel). 2023. Effects of Methyl Sulfonyl Methane and Selenium Yeast on Fatty Liver Syndrome in Laying Hens and Their Biological Mechanisms. doi:10.3390/ani13152466 PubMed
- [18] Lyubka Tancheva et al.. Antioxidants (Basel). 2023. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. doi:10.3390/antiox12122050 PubMed
- [19] Félix Javier Jiménez-Jiménez et al.. Antioxidants (Basel). 2022. Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. doi:10.3390/antiox11020272 PubMed
- [20] Yoo Bhin Kim et al.. Anim Biosci. 2022. Effects of dietary methyl sulfonyl methane and selenium on laying performance, egg quality, gut health indicators, and antioxidant capacity of … doi:10.5713/ab.21.0564 PubMed
- [21] Chengxin Shi et al.. J Inflamm Res. 2021. Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation. doi:10.2147/JIR.S288412 PubMed
- [22] Tian-Tian Meng et al.. Biol Trace Elem Res. 2021. Nanoselenium and Selenium Yeast Have Minimal Differences on Egg Production and Se Deposition in Laying Hens. doi:10.1007/s12011-020-02349-8 PubMed
- [23] Silvia Maggini et al.. Nutr Hosp. 2021. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. doi:10.20960/nh.03788 PubMed
- [24] Shaun A Mason et al.. Redox Biol. 2020. Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights. doi:10.1016/j.redox.2020.101471 PubMed
- [25] Sheeana Gangadoo et al.. Environ Sci Pollut Res Int. 2020. Nanoparticles of selenium as high bioavailable and non-toxic supplement alternatives for broiler chickens. doi:10.1007/s11356-020-07962-7 PubMed
- [26] Marek Kieliszek. Molecules. 2019. Selenium⁻Fascinating Microelement, Properties and Sources in Food. doi:10.3390/molecules24071298 PubMed
- [27] I P Hargreaves et al.. Br J Hosp Med (Lond). 2019. Supplementation with selenium and coenzyme Q10 in critically ill patients. doi:10.12968/hmed.2019.80.10.589 PubMed
- [28] Małgorzata Kiełczykowska et al.. Adv Clin Exp Med. 2018. Selenium - a fascinating antioxidant of protective properties. doi:10.17219/acem/67222 PubMed
- [29] Rosa María Martínez García et al.. Nutr Hosp. 2018. [Nutrition strategies that improve cognitive function]. doi:10.20960/nh.2281 PubMed
- [30] Richard J Kryscio et al.. JAMA Neurol. 2017. Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE). doi:10.1001/jamaneurol.2016.5778 PubMed
- [31] Anthony V Perkins et al.. Placenta. 2016. Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium. doi:10.1016/j.placenta.2016.02.007 PubMed
- [32] Mahmood Habibian et al.. Biol Trace Elem Res. 2015. Selenium as a feed supplement for heat-stressed poultry: a review. doi:10.1007/s12011-015-0275-x PubMed
- [33] Margaret P Rayman et al.. Free Radic Biol Med. 2013. Epidemiology of selenium and type 2 diabetes: can we make sense of it? doi:10.1016/j.freeradbiomed.2013.04.003 PubMed
- [34] Nicole Metes-Kosik et al.. Mol Nutr Food Res. 2012. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. doi:10.1002/mnfr.201200386 PubMed
- [35] Huimin Yan et al.. Biol Trace Elem Res. 2012. Antioxidant and antitumor activities of selenium- and zinc-enriched oyster mushroom in mice. doi:10.1007/s12011-012-9454-1 PubMed
- [36] Maria Luisa Ojeda et al.. Alcohol Clin Exp Res. 2012. Selenium or selenium plus folic acid-supplemented diets ameliorate renal oxidation in ethanol-exposed pups. doi:10.1111/j.1530-0277.2012.01788.x PubMed
- [37] Mark C Houston. J Clin Hypertens (Greenwich). 2011. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. doi:10.1111/j.1751-7176.2011.00489.x PubMed
- [38] John P Richie et al.. Nutr Cancer. 2011. Association of selenium status and blood glutathione concentrations in blacks and whites. doi:10.1080/01635581.2011.535967 PubMed
- [39] Maria G Boosalis. Nutr Clin Pract. 2008. The role of selenium in chronic disease. doi:10.1177/0884533608314532 PubMed
- [40] C K Sen et al.. Am J Clin Nutr. 2000. Thiol homeostasis and supplements in physical exercise. doi:10.1093/ajcn/72.2.653S PubMed
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