Selenium para Oxidative Stress (Cardiovascular)
B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
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B
Conclusão
KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
Key Study Findings
animal study
Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …
Dose: zinc and/or selenium supplementation; doses not specified in abstract
vs: Placebo
Efeito: None
None
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A …
Dose: None
vs: None
Outcome: MASLD treatment and prevention
Efeito: None
None
População: Patients with metabolic steatotic liver disease (review)
Review
Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: People with depression
preclinical animal study with human correlational observation
Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment.
Dose: oral administration; specific dose not reported in abstract
vs: Placebo
Efeito: None
None
Review
The Role of Various Types of Diets in the Treatments of Depressive Disorders.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Adults with depression
prospective controlled study
n=30
Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …
Dose: None
vs: Placebo
Efeito: None
None
Key Statistics
3
Estudos
600
Participantes
↑
Positive
B
Nota
Referenced Papers
Environment international
2026
Biomaterials
2025
8 citações
Nutrients
2025
3 citações
Cutaneous and ocular …
2025
1 citações
Medicina (Kaunas, Lithuania)
2025
1 citações
Biogerontology
2025
International journal of …
2025
Molecules (Basel, Switzerland)
2024
13 citações
Food & function
2024
6 citações
Journal of dairy …
2024
4 citações
Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis.
Meta-Analysis
Biological trace element …
2024
2 citações
Nutrients
2023
75 citações
International journal of …
2023
45 citações
BMC endocrine disorders
2023
25 citações
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Review
Metabolites
2023
13 citações
Journal of animal …
2023
11 citações
Animals : an …
2023
7 citações
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Other
Antioxidants (Basel, Switzerland)
2023
5 citações
Antioxidants (Basel, Switzerland)
2022
13 citações
Animal bioscience
2022
9 citações
Journal of inflammation …
2021
34 citações
Biological trace element …
2021
18 citações
Nutricion hospitalaria
2021
10 citações
Redox biology
2020
184 citações
Environmental science and …
2020
79 citações
Molecules (Basel, Switzerland)
2019
472 citações
British journal of …
2019
14 citações
Advances in clinical …
2018
200 citações
Nutricion hospitalaria
2018
32 citações
JAMA neurology
2017
258 citações
Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium.
Review
Placenta
2016
23 citações
Biological trace element …
2015
1 citações
Free radical biology …
2013
208 citações
Molecular nutrition & …
2012
65 citações
Biological trace element …
2012
31 citações
Alcoholism, clinical and …
2012
19 citações
Journal of clinical …
2011
396 citações
Nutrition and cancer
2011
19 citações
Nutrition in clinical …
2008
125 citações
The American journal …
2000
472 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 55 mcg/day
- cardiovascularantioxidant:
- 100-200 mcg/day
Limite superior: 400 mcg/day (risk of selenosis above this level)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| zinc and/or selenium supplementation; doses not specified in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| oral administration; specific dose not reported in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | 30 |
| None | -- | Negative | 2065 |
| None | -- | Positive | -- |
Melhor horário: With meals
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
- ⚠ GI discomfort at moderate-high doses
- ⚠ Potential increased type 2 diabetes risk at high supplemental doses
Interações Conhecidas
- ● Cisplatin and other chemotherapy drugs (may affect efficacy)
- ● Statins (may enhance antioxidant effects)
- ● CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
Ingestão máxima tolerável: 400 mcg/day (risk of selenosis above this level)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Selenium help with Oxidative Stress (Cardiovascular)?
Based on 3 studies with 600 participants, there is moderate evidence from clinical studies that Selenium may support Oxidative Stress (Cardiovascular) management. Our evidence grade is B (Good Evidence).
How much Selenium should I take for Oxidative Stress (Cardiovascular)?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Selenium?
Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Selenium and Oxidative Stress (Cardiovascular)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Oxidative Stress (Cardiovascular)
Selenium para outras condições
References
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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.