Selenium для Oxidative Stress (Cardiovascular)
B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
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B
Итог
KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
Key Study Findings
animal study
Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …
Dose: zinc and/or selenium supplementation; doses not specified in abstract
или: Placebo
Эффект: None
None
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A …
Dose: None
или: None
Outcome: MASLD treatment and prevention
Эффект: None
None
Популяция: Patients with metabolic steatotic liver disease (review)
Review
Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: People with depression
preclinical animal study with human correlational observation
Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment.
Dose: oral administration; specific dose not reported in abstract
или: Placebo
Эффект: None
None
Review
The Role of Various Types of Diets in the Treatments of Depressive Disorders.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Adults with depression
prospective controlled study
n=30
Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …
Dose: None
или: Placebo
Эффект: None
None
Key Statistics
3
Исследования
600
Участники
↑
Positive
B
Оценка
Referenced Papers
Environment international
2026
Biomaterials
2025
8 цитирований
Nutrients
2025
3 цитирований
Cutaneous and ocular …
2025
1 цитирований
Medicina (Kaunas, Lithuania)
2025
1 цитирований
Biogerontology
2025
International journal of …
2025
Molecules (Basel, Switzerland)
2024
13 цитирований
Food & function
2024
6 цитирований
Journal of dairy …
2024
4 цитирований
Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis.
Meta-Analysis
Biological trace element …
2024
2 цитирований
Nutrients
2023
75 цитирований
International journal of …
2023
45 цитирований
BMC endocrine disorders
2023
25 цитирований
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Review
Metabolites
2023
13 цитирований
Journal of animal …
2023
11 цитирований
Animals : an …
2023
7 цитирований
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Other
Antioxidants (Basel, Switzerland)
2023
5 цитирований
Antioxidants (Basel, Switzerland)
2022
13 цитирований
Animal bioscience
2022
9 цитирований
Journal of inflammation …
2021
34 цитирований
Biological trace element …
2021
18 цитирований
Nutricion hospitalaria
2021
10 цитирований
Redox biology
2020
184 цитирований
Environmental science and …
2020
79 цитирований
Molecules (Basel, Switzerland)
2019
472 цитирований
British journal of …
2019
14 цитирований
Advances in clinical …
2018
200 цитирований
Nutricion hospitalaria
2018
32 цитирований
JAMA neurology
2017
258 цитирований
Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium.
Review
Placenta
2016
23 цитирований
Biological trace element …
2015
1 цитирований
Free radical biology …
2013
208 цитирований
Molecular nutrition & …
2012
65 цитирований
Biological trace element …
2012
31 цитирований
Alcoholism, clinical and …
2012
19 цитирований
Journal of clinical …
2011
396 цитирований
Nutrition and cancer
2011
19 цитирований
Nutrition in clinical …
2008
125 цитирований
The American journal …
2000
472 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 55 mcg/day
- cardiovascularantioxidant:
- 100-200 mcg/day
Верхний предел: 400 mcg/day (risk of selenosis above this level)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| zinc and/or selenium supplementation; doses not specified in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| oral administration; specific dose not reported in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | 30 |
| None | -- | Negative | 2065 |
| None | -- | Positive | -- |
Лучшее время приёма: With meals
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
- ⚠ GI discomfort at moderate-high doses
- ⚠ Potential increased type 2 diabetes risk at high supplemental doses
Известные взаимодействия
- ● Cisplatin and other chemotherapy drugs (may affect efficacy)
- ● Statins (may enhance antioxidant effects)
- ● CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
Допустимый верхний уровень потребления: 400 mcg/day (risk of selenosis above this level)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Selenium help with Oxidative Stress (Cardiovascular)?
Based on 3 studies with 600 participants, there is moderate evidence from clinical studies that Selenium may support Oxidative Stress (Cardiovascular) management. Our evidence grade is B (Good Evidence).
How much Selenium should I take for Oxidative Stress (Cardiovascular)?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Selenium?
Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Selenium and Oxidative Stress (Cardiovascular)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Oxidative Stress (Cardiovascular)
Selenium для других состояний
References
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