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Selenium untuk Coronary Artery Disease (CAD)

C

SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

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            C

        

        

            
Kesimpulan

            
            
SELECT trial was negative as monotherapy. KiSel-10 was positive in combination with CoQ10. U-shaped dose response — research suggests benefit only in deficient populations (serum <100 mcg/L).

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studi

    

    

        
10000

        
Peserta

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
Peringkat

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
55 mcg/day

                    

                    
                    

                        
cardiovascularantioxidant:

                        
100-200 mcg/day

                    

                    
                

                
                

                    Batas atas: 400 mcg/day (risk of selenosis above this level)
                

                
            

            

            

            
            

                Waktu terbaik diminum: With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort at moderate-high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased type 2 diabetes risk at high supplemental doses
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Cisplatin and other chemotherapy drugs (may affect efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Statins (may enhance antioxidant effects)
                        
    • 
                        
                        
  • 
                            ●
                            CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                        
    • 
                        
                    

                

                

                
                

                    

                        Asupan atas yang dapat ditoleransi: 400 mcg/day (risk of selenosis above this level)
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Selenium help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 5 studies with 10,000 participants, there is limited but promising evidence that Selenium may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Selenium should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Selenium?
            
        
        

            Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Selenium and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 10,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Selenium untuk kondisi lain

                    

                        
                        
                            Oxidative Stress (Cardiovascular)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        Penafian FDA:
        Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.