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L-Citrulline for High Blood Pressure (Hypertension)

C

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

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The Bottom Line

            
            
Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
7

        
Studies

    

    

        
400

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
lcitrulline:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
citrullinemalate:

                        
6,000-8,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
3,000 mg/day

                    

                    
                

                
                

                    Upper limit: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                

                
            

            

            

            
            

                Best taken: On empty stomach; divide doses for sustained arginine elevation
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Generally well-tolerated
                        
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                            ⚠
                            Mild gastrointestinal discomfort at high doses
                        
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                            ⚠
                            Heartburn (rare)
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
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                            PDE5 inhibitors (excessive vasodilation risk)
                        
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                            Nitrates (excessive vasodilation risk)
                        
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                        Tolerable upper intake: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Citrulline help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 7 studies with 400 participants, there is limited but promising evidence that L-Citrulline may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Citrulline should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Citrulline?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Citrulline and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.