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Hawthorn for High Blood Pressure (Hypertension)

C Some Evidence Limited evidence from small studies, but some positive signals exist.

Some studies show modest BP reduction as secondary outcome in heart failure trials. Dedicated hypertension trials are limited. ACE-inhibitory mechanism is plausible.

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            C

        

        

            
The Bottom Line

            
            
Some studies show modest BP reduction as secondary outcome in heart failure trials. Dedicated hypertension trials are limited. ACE-inhibitory mechanism is plausible.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Supplements for Lipid Lowering: What Does the Evidence Show?
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: lipid levels
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Studies

    

    

        
300

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Supplements for Lipid Lowering: What Does the Evidence Show?
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Current cardiology reports
                        2023
                        
                        7 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
450-900 mg/day standardized extract (WS 1442 or LI 132)

                    

                    
                    

                        
standardization:

                        
18.75% OPCs or 2.2% flavonoids

                    

                    
                

                
                

                    Upper limit: Not formally established; up to 1,800 mg/day used in the SPICE trial
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals; effects require 6-8 weeks of continuous use
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Dizziness
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Cardiac glycosides (digoxin — may enhance inotropic effects)
                        
    • 
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            Beta-blockers (additive cardiac effects)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (additive vasodilation)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established; up to 1,800 mg/day used in the SPICE trial
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Hawthorn help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 4 studies with 300 participants, there is limited but promising evidence that Hawthorn may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Hawthorn should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 450-900 mg/day standardized extract (WS 1442 or LI 132). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Hawthorn?
            
        
        

            Reported side effects may include Generally well-tolerated, Dizziness, Nausea, Gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Hawthorn and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Hawthorn for other conditions

                    

                        
                        
                            Heart Failure
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Saeid Mirzai et al..
      Curr Cardiol Rep.
      2023.
      Supplements for Lipid Lowering: What Does the Evidence Show?
      doi:10.1007/s11886-023-01903-9
      PubMed
    
    2. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.