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HeartCited

Hawthorn
Hawthorn

herb

别名: Crataegus, Crataegus monogyna, Crataegus laevigata, Hawthorne, Whitethorn

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About





            

                
Hawthorn berry/leaf/flower extract contains OPCs and flavonoids that improve cardiac contractile force without increasing oxygen demand. A 2008 Cochrane review of 14 RCTs (1,110 heart failure patients) found hawthorn significantly improved exercise tolerance and reduced dyspnea. Hawthorn is approved by the German Commission E for declining cardiac function (NYHA I-II).

            

        

        

        
        
        

            

  
How It Works





            

                
Oligomeric procyanidins and flavonoids inhibit phosphodiesterase-3 (PDE3) increasing cardiac cAMP and improving contractile force (positive inotropic effect without increasing oxygen demand); enhances coronary artery blood flow via endothelium-dependent vasodilation; reduces peripheral vascular resistance; antioxidant flavonoids protect against myocardial ischemia-reperfusion injury; mild ACE-inhibitory activity.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Heart Failure
                                    
                                
                                
                                    B

                                
                                
                                    14
                                
                                
                                    3800
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    4
                                
                                
                                    300
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated
                
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                    Dizziness
                
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                    Nausea
                
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                    Gastrointestinal discomfort
                
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                    Headache
                
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Drug & Supplement Interactions





            
    
                
                
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                    Cardiac glycosides (digoxin — may enhance inotropic effects)
                
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                    Antihypertensives (additive blood pressure lowering)
                
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                    Beta-blockers (additive cardiac effects)
                
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                    PDE5 inhibitors (additive vasodilation)
                
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Related Ingredients





            

                
                
                    Garlic
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Berberine
                    
                
                
                
                    Red Yeast Rice
                    
                
                
            

        

        
    


    
    












    

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