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Berberine
Berberine

herb

别名: Berberine HCl, Berberine Hydrochloride, Goldenseal Extract, Coptis chinensis

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About





            

                
Berberine activates AMPK, the master metabolic switch, and upregulates LDL receptors via PCSK9 inhibition — a mechanism distinct from and complementary to statins. A landmark 2004 RCT found berberine at 500 mg BID reduced LDL by 25%, triglycerides by 35%, and total cholesterol by 29% — comparable to moderate-dose statins. A 2024 meta-analysis of 46 RCTs confirmed these findings.

            

        

        

        
        
        

            

  
How It Works





            

                
Activates AMPK in hepatocytes, adipocytes, and skeletal muscle; upregulates LDL receptor expression by stabilizing LDLR mRNA via PCSK9 inhibition, increasing hepatic LDL clearance by a mechanism distinct from statins; reduces hepatic cholesterol synthesis via HMG-CoA reductase inhibition; improves insulin sensitivity by enhancing GLUT4 translocation; inhibits intestinal cholesterol absorption.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Cholesterol (Hyperlipidemia)
                                    
                                
                                
                                    B

                                
                                
                                    46
                                
                                
                                    5000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Metabolic Syndrome (Cardiovascular Aspects)
                                    
                                
                                
                                    B

                                
                                
                                    20
                                
                                
                                    2500
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    8
                                
                                
                                    600
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Diarrhea (most common, usually resolves in 2 weeks)
                
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                    Constipation
                
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                    Flatulence
                
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                    Abdominal pain
                
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                    May lower blood sugar (monitor in diabetics)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Metformin (additive blood sugar lowering; may increase metformin levels)
                
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                    CYP2D6 and CYP3A4 substrates (berberine is a CYP inhibitor)
                
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                    Cyclosporine (may increase blood levels)
                
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                    Macrolide antibiotics (may prolong QT interval)
                
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                    Statins (complementary mechanism; monitor for additive effects)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Hawthorn
                    
                
                
                
                    Garlic
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Red Yeast Rice
                    
                
                
            

        

        
    


    
    












    

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