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Berberine 用于 高胆固醇血症（高脂血症）

B 证据 至少一项随机试验支持这一结论，结果基本一致。

LDL reduction 15-25%, comparable to moderate-dose statins. Unique mechanism (PCSK9 inhibition) may be complementary to statins. Particularly strong evidence from Chinese clinical trials.

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            B

        

        

            
结论

            
            
LDL reduction 15-25%, comparable to moderate-dose statins. Unique mechanism (PCSK9 inhibition) may be complementary to statins. Particularly strong evidence from Chinese clinical trials.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Gut microbiota balance
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: General population (traditional medicine review)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
46

        
研究数量

    

    

        
5000

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Indian journal of …
                        2024
                        
                        2 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
500-1,500 mg/day divided TID

                    

                    
                    

                        
lipidsupport:

                        
500 mg TID with meals

                    

                    
                

                
                

                    上限： Not formally established; GI side effects limit doses >1,500 mg/day
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： With meals, divided TID for sustained plasma levels; short half-life
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Diarrhea (most common, usually resolves in 2 weeks)
                        
    • 
                        
                        
  • 
                            ⚠
                            Constipation
                        
    • 
                        
                        
  • 
                            ⚠
                            Flatulence
                        
    • 
                        
                        
  • 
                            ⚠
                            Abdominal pain
                        
    • 
                        
                        
  • 
                            ⚠
                            May lower blood sugar (monitor in diabetics)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Metformin (additive blood sugar lowering; may increase metformin levels)
                        
    • 
                        
                        
  • 
                            ●
                            CYP2D6 and CYP3A4 substrates (berberine is a CYP inhibitor)
                        
    • 
                        
                        
  • 
                            ●
                            Cyclosporine (may increase blood levels)
                        
    • 
                        
                        
  • 
                            ●
                            Macrolide antibiotics (may prolong QT interval)
                        
    • 
                        
                        
  • 
                            ●
                            Statins (complementary mechanism; monitor for additive effects)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not formally established; GI side effects limit doses >1,500 mg/day
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Berberine help with 高胆固醇血症（高脂血症）?
            
        
        

            Based on 46 studies with 5,000 participants, there is moderate evidence from clinical studies that Berberine may support 高胆固醇血症（高脂血症） management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Berberine should I take for 高胆固醇血症（高脂血症）?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-1,500 mg/day divided TID. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Berberine?
            
        
        

            Reported side effects may include Diarrhea (most common, usually resolves in 2 weeks), Constipation, Flatulence, Abdominal pain. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Berberine and 高胆固醇血症（高脂血症）?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 46 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Devi Datt Joshi et al..
      Indian J Microbiol.
      2024.
      Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance.
      doi:10.1007/s12088-024-01251-4
      PubMed
    
    2. 
    
  















    

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