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HeartCited

Resveratrol for Atherosclerosis

C

Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.

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            C

        

        

            
The Bottom Line

            
            
Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studies

    

    

        
400

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
150-500 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
250-500 mg/day trans-resveratrol

                    

                    
                

                
                

                    Upper limit: Not formally established; GI discomfort common above 1,000 mg/day
                

                
            

            

            

            
            

                Best taken: With meals; bioavailability enhanced by piperine co-supplementation
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
                        
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                            Headache
                        
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                            May have estrogenic activity at high doses
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            Anticoagulants (may inhibit platelet aggregation)
                        
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                            CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
                        
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                            Blood pressure medications (additive hypotensive effect)
                        
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                            Estrogen-sensitive conditions (weak estrogenic activity)
                        
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                        Tolerable upper intake: Not formally established; GI discomfort common above 1,000 mg/day
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Resveratrol help with Atherosclerosis?
            
        
        

            Based on 5 studies with 400 participants, there is limited but promising evidence that Resveratrol may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Resveratrol should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Resveratrol?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Resveratrol and Atherosclerosis?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Resveratrol for other conditions

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.