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HeartCited

Quercetin for Atherosclerosis

D Early Research Only preliminary research exists (lab studies, case reports).

In vitro evidence for PCSK9 inhibition and reduced foam cell formation. Limited human data on atherosclerosis endpoints specifically.

D

The Bottom Line

In vitro evidence for PCSK9 inhibition and reduced foam cell formation. Limited human data on atherosclerosis endpoints specifically.

Key Statistics

2

Studies

100

Participants

↑

Positive

D

Grade

Referenced Papers

Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating Allergic Rhinitis Mouse Model based … Other
Current computer-aided drug … 2025 2 citations
Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin … Other
Iranian journal of … 2024 4 citations
Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. Review
Pharmacological research 2019 31 citations
Dietary Polyphenols in the Prevention of Stroke. Review
Oxidative medicine and … 2017 87 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:
500-1,000 mg/day
bloodpressuresupport:
500-730 mg/day

Upper limit: Not formally established; up to 1,000 mg/day used in clinical trials

Best taken: With meals; vitamin C co-supplementation may enhance bioavailability

Safety & Side Effects

Reported Side Effects

  • ⚠ Generally well-tolerated
  • ⚠ Headache (rare)
  • ⚠ Mild gastrointestinal discomfort
  • ⚠ Tingling in extremities (rare, high doses)

Known Interactions

  • ● Antibiotics (quinolones — may reduce efficacy)
  • ● Cyclosporine (may increase blood levels)
  • ● Anticoagulants (may have mild antiplatelet effect)
  • ● Blood pressure medications (additive effect)

Tolerable upper intake: Not formally established; up to 1,000 mg/day used in clinical trials

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Quercetin help with Atherosclerosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Quercetin may support Atherosclerosis management. Our evidence grade is D (Very Early Research).
How much Quercetin should I take for Atherosclerosis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Generally well-tolerated, Headache (rare), Mild gastrointestinal discomfort, Tingling in extremities (rare, high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Atherosclerosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Quercetin for other conditions

High Blood Pressure (Hypertension) B

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References

  
    
    
    
  1. 
      [1]
      Sihong Huang et al..
      Curr Comput Aided Drug Des.
      2025.
      Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating Allergic Rhinitis Mouse Model based …
      doi:10.2174/0115734099299714240516160158
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Masoumeh Shamsi et al..
      Iran J Pharm Res.
      2024.
      Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin …
      doi:10.5812/ijpr-151428
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Wang Anlu et al..
      Pharmacol Res.
      2019.
      Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease.
      doi:10.1016/j.phrs.2019.02.018
      PubMed
    
    4. 
    
    
  4. 
      [4]
      A Tressera-Rimbau et al..
      Oxid Med Cell Longev.
      2017.
      Dietary Polyphenols in the Prevention of Stroke.
      doi:10.1155/2017/7467962
      PubMed
    
    5. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.