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Vitamin K2
Vitamin K2

vitamin

别名: Menaquinone, MK-7, MK-4, Menaquinone-7, Menaquinone-4

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About





            

                
Vitamin K2 activates matrix Gla protein (MGP), the most potent natural inhibitor of arterial calcification, directing calcium to bones and away from arteries. The Rotterdam Heart Study (4,807 participants) found the highest vitamin K2 intake was associated with 57% reduction in cardiovascular mortality and 52% reduction in severe aortic calcification.

            

        

        

        
        
        

            

  
How It Works





            

                
Activates matrix Gla protein (MGP) — the most potent natural inhibitor of arterial calcification — through gamma-carboxylation; directs calcium deposition to bones and away from arteries by activating osteocalcin (bone) and MGP (arteries); the MK-7 form has the longest half-life (72 hours) providing sustained vascular protection; works synergistically with vitamin D.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Arterial Stiffness
                                    
                                
                                
                                    B

                                
                                
                                    5
                                
                                
                                    1200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally very well-tolerated
                
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                    Does not affect blood clotting (INR) at supplemental doses, unlike K1
                
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Drug & Supplement Interactions





            
    
                
                
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                    Warfarin (patients on warfarin should consult physician before K2 supplementation)
                
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                    Vitamin D (synergistic — D increases MGP production, K2 activates it)
                
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Related Ingredients





            

                
                
                    Vitamin D
                    
                
                
                
                    Niacin (Vitamin B3)
                    
                
                
                
                    Folate (Vitamin B9)
                    
                
                
                
                    Vitamin E
                    
                
                
            

        

        
    


    
    












    

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