What is the recommended dosage for Vitamin K2?

General: 90-120 mcg/day (MK-7 preferred); Cardiovascular Support: 180-360 mcg/day MK-7

What are the side effects of Vitamin K2?

Potential side effects include: Generally very well-tolerated, Does not affect blood clotting (INR) at supplemental doses, unlike K1.

What is vitamin K2 and how may it support cardiovascular health?

Vitamin K2 (menaquinone) activates matrix Gla protein (MGP), which inhibits arterial calcification. Observational studies suggest higher K2 intake is associated with reduced cardiovascular mortality and coronary calcification. The Rotterdam Study found that high K2 intake was associated with 50% lower risk of arterial calcification.

What dosage of vitamin K2 has been studied for cardiovascular benefits?

Clinical studies have used 90–360 mcg of vitamin K2 per day, primarily the MK-7 form. MK-7 has a longer half-life than MK-4, allowing once-daily dosing. Studies examining arterial stiffness and calcification typically lasted 1–3 years. K2 is often co-supplemented with vitamin D.

What are the potential side effects of vitamin K2?

K2 is generally well tolerated at supplemental doses. The critical interaction is with warfarin (and other vitamin K antagonist anticoagulants), where K2 can reduce anticoagulant efficacy. Individuals on warfarin must maintain consistent vitamin K intake and inform their healthcare provider before starting K2 supplementation.

Vitamin K2
Vitamin K2

vitamin

Também conhecido como: Menaquinone, MK-7, MK-4, Menaquinone-7, Menaquinone-4

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About

Vitamin K2 activates matrix Gla protein (MGP), the most potent natural inhibitor of arterial calcification, directing calcium to bones and away from arteries. The Rotterdam Heart Study (4,807 participants) found the highest vitamin K2 intake was associated with 57% reduction in cardiovascular mortality and 52% reduction in severe aortic calcification.

How It Works

Activates matrix Gla protein (MGP) — the most potent natural inhibitor of arterial calcification — through gamma-carboxylation; directs calcium deposition to bones and away from arteries by activating osteocalcin (bone) and MGP (arteries); the MK-7 form has the longest half-life (72 hours) providing sustained vascular protection; works synergistically with vitamin D.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Arterial Stiffness	B	5	1200	Ver →

Side Effects

Generally very well-tolerated
Does not affect blood clotting (INR) at supplemental doses, unlike K1

Drug & Supplement Interactions

Warfarin (patients on warfarin should consult physician before K2 supplementation)
Vitamin D (synergistic — D increases MGP production, K2 activates it)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Vitamin D Niacin (Vitamin B3) Folate (Vitamin B9) Vitamin E

Dados Rápidos

Dosagem: General: 90-120 mcg/day (MK-7 preferred); Cardiovascular_Support: 180-360 mcg/day MK-7
Formas: capsule softgel liquid drops
Fontes Naturais: Natto (richest source, MK-7), Gouda/Brie cheese, Egg yolks, Chicken liver, Sauerkraut
Limite Superior: Not established (no known toxicity for K2 at supplemental doses)
Melhor Horário: With meals containing fat; can combine with vitamin D supplement

Resumo das Evidências

Arterial Stiffness B

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.