Skip to main content
HeartCited

Vitamin E
Vitamin E

vitamin

Também conhecido como: Alpha-Tocopherol, d-Alpha-Tocopherol, Mixed Tocopherols, Tocotrienols

<\/script>\n
`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dvitamin\u002De'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    






    
    

        
        
        

            

  
About





            

                
Vitamin E is the primary lipid-soluble antioxidant in LDL particles and cell membranes. Despite strong mechanistic rationale, large RCTs have been disappointing. The HOPE trial (9,541 participants) found no cardiovascular benefit at 400 IU/day, and a 2005 meta-analysis found high-dose vitamin E (>=400 IU/day) was associated with increased all-cause mortality. Current AHA guidelines do not recommend vitamin E supplementation.

            

        

        

        
        
        

            

  
How It Works





            

                
Primary lipid-soluble antioxidant in LDL particles and cell membranes; inhibits LDL oxidation — a key early step in atherogenesis; modulates inflammatory gene expression via NF-kB inhibition; inhibits platelet adhesion and smooth muscle cell proliferation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                Condição
                                Nota
                                Estudos
                                Participantes
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Atherosclerosis
                                    
                                
                                
                                    C

                                
                                
                                    15
                                
                                
                                    50000
                                
                                
                                    
                                        Ver →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
  • 
                    
                    Increased bleeding risk at high doses
                
    • 
                
                
  • 
                    
                    Possible increased all-cause mortality at >=400 IU/day
                
    • 
                
                
  • 
                    
                    Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
                
    • 
                
                
  • 
                    
                    Nausea, diarrhea, fatigue at high doses
                
    • 
                
            

        

        

        
        
        

            

  
Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    Anticoagulants (increased bleeding risk)
                
    • 
                
                
  • 
                    
                    Statins and niacin (may blunt HDL-raising effect)
                
    • 
                
                
  • 
                    
                    Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
                
    • 
                
                
  • 
                    
                    Vitamin K (may antagonize at high doses)
                
    • 
                
            

            

                Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin D
                    
                
                
                
                    Vitamin K2
                    
                
                
                
                    Niacin (Vitamin B3)
                    
                
                
                
                    Folate (Vitamin B9)
                    
                
                
            

        

        
    


    
    












    

        Aviso Legal da FDA:
        Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.