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Nattokinase
Nattokinase

amino_acid

别名: Subtilisin NAT, NSK-SD, Natto Extract, Bacillus subtilis var. natto Protease

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About





            

                
Nattokinase is a serine protease from fermented soybeans that directly degrades fibrin and enhances endogenous fibrinolytic activity. A 2021 RCT (79 participants with subclinical atherosclerosis) showed nattokinase at 2,000 FU/day reduced carotid intima-media thickness progression over 12 months. It also demonstrated modest blood pressure reductions in meta-analyses.

            

        

        

        
        
        

            

  
How It Works





            

                
A serine protease that directly degrades fibrin through fibrinolytic activity and enhancement of endogenous t-PA while inhibiting PAI-1; reduces blood viscosity by decreasing fibrinogen and factor VIII levels; may reduce blood pressure through ACE-inhibitory activity; anti-atherosclerotic effects via LDL reduction.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Atherosclerosis
                                    
                                
                                
                                    B

                                
                                
                                    4
                                
                                
                                    300
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    6
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated
                
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                    Increased bleeding risk (fibrinolytic activity)
                
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                    Mild gastrointestinal discomfort
                
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                    Bruising (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants — warfarin, DOACs (additive anticoagulant effects — contraindicated)
                
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                    Antiplatelet drugs (additive bleeding risk)
                
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                    NSAIDs (increased bleeding risk)
                
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                    Fish oil at high doses (additive anticoagulant effect)
                
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Related Ingredients





            

                
                
                    L-Arginine
                    
                
                
                
                    L-Citrulline
                    
                
                
                
                    Taurine
                    
                
                
            

        

        
    


    
    












    

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