What is the recommended dosage for Nattokinase?

General: 2,000 FU (fibrinolytic units)/day; Cardiovascular Support: 2,000-4,000 FU/day

What are the side effects of Nattokinase?

Potential side effects include: Generally well-tolerated, Increased bleeding risk (fibrinolytic activity), Mild gastrointestinal discomfort, Bruising (rare).

What is nattokinase and how may it support cardiovascular health?

Nattokinase is a fibrinolytic enzyme derived from natto, a traditional Japanese fermented soybean food. In vitro studies show it can break down fibrin, a blood clotting protein. Some clinical studies suggest it may reduce blood pressure, improve lipid profiles, and inhibit platelet aggregation. It is widely used in Japan and Korea.

What dosage of nattokinase has been studied in clinical trials?

Clinical studies have used 2,000–10,000 fibrinolytic units (FU) per day, typically equivalent to 100–200 mg. Blood pressure studies commonly used 2,000 FU daily for 8 weeks. The enzyme is measured in fibrinolytic units (FU) or fibrin degradation units (FDU). NSK-SD is a commonly studied form.

What are the potential side effects of nattokinase?

Nattokinase has significant anticoagulant effects and should not be combined with blood thinners (warfarin, heparin, aspirin, clopidogrel) due to serious bleeding risk. Discontinue at least 2 weeks before surgery. It should be avoided by individuals with bleeding disorders. Individuals with soybean allergies should use purified NSK-SD form.

Nattokinase
Nattokinase

amino_acid

Noto anche come: Subtilisin NAT, NSK-SD, Natto Extract, Bacillus subtilis var. natto Protease

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About

Nattokinase is a serine protease from fermented soybeans that directly degrades fibrin and enhances endogenous fibrinolytic activity. A 2021 RCT (79 participants with subclinical atherosclerosis) showed nattokinase at 2,000 FU/day reduced carotid intima-media thickness progression over 12 months. It also demonstrated modest blood pressure reductions in meta-analyses.

How It Works

A serine protease that directly degrades fibrin through fibrinolytic activity and enhancement of endogenous t-PA while inhibiting PAI-1; reduces blood viscosity by decreasing fibrinogen and factor VIII levels; may reduce blood pressure through ACE-inhibitory activity; anti-atherosclerotic effects via LDL reduction.

Evidence For Conditions

Condizione	Grado	Studi	Partecipanti
Atherosclerosis	B	4	300	Visualizza →
High Blood Pressure (Hypertension)	C	6	400	Visualizza →

Side Effects

Generally well-tolerated
Increased bleeding risk (fibrinolytic activity)
Mild gastrointestinal discomfort
Bruising (rare)

Drug & Supplement Interactions

Anticoagulants — warfarin, DOACs (additive anticoagulant effects — contraindicated)
Antiplatelet drugs (additive bleeding risk)
NSAIDs (increased bleeding risk)
Fish oil at high doses (additive anticoagulant effect)

Informare sempre il proprio medico di tutti gli integratori che si assumono.Informate sempre il vostro medico di tutti gli integratori che assumete.

Related Ingredients

L-Arginine L-Citrulline Taurine

Informazioni rapide

Dosaggio: General: 2,000 FU (fibrinolytic units)/day; Cardiovascular_Support: 2,000-4,000 FU/day
Forme: capsule tablet
Fonti naturali: Natto (Japanese fermented soybeans)
Limite massimo: Not formally established; up to 10,800 FU/day used in clinical trials
Momento migliore: On empty stomach (between meals) for optimal fibrinolytic activity

Riepilogo delle evidenze

Atherosclerosis B

High Blood Pressure (Hypertension) C

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.