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Cocoa Flavanols
Cocoa Flavanols

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别名: Cocoa Polyphenols, Cocoa Extract, Dark Chocolate Flavanols, Epicatechin, CocoaVia

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About





            

                
Cocoa flavanols, particularly (-)-epicatechin, activate endothelial nitric oxide synthase improving flow-mediated dilation. The COSMOS trial (21,442 participants, 3.6 years) — the largest flavanol supplement trial ever — found cocoa extract at 500 mg/day reduced cardiovascular mortality by 27%. EFSA has approved a health claim for cocoa flavanols and vascular elasticity.

            

        

        

        
        
        

            

  
How It Works





            

                
(-)-Epicatechin and related procyanidins activate endothelial nitric oxide synthase (eNOS) via PI3K/Akt signaling; sustained NO production improves flow-mediated dilation; inhibit NADPH oxidase reducing superoxide-mediated NO degradation; reduce platelet reactivity; improve insulin sensitivity and reduce blood pressure through arterial compliance improvement.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Endothelial Dysfunction
                                    
                                
                                
                                    A

                                
                                
                                    30
                                
                                
                                    25000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    20
                                
                                
                                    1000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Mild gastrointestinal discomfort
                
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                    Caffeine-related effects (insomnia, nervousness — from cocoa/chocolate sources)
                
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                    Headache (rare)
                
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                    Weight gain (if consuming as chocolate rather than extract)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (mild antiplatelet effect at high doses)
                
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                    MAO inhibitors (cocoa contains tyramine)
                
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                    Adenosine (caffeine in cocoa may antagonize)
                
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                    Blood pressure medications (additive hypotensive effect)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Nitric Oxide Boosters
                    
                
                
                
                    Beetroot Extract
                    
                
                
                
                    Olive Leaf Extract
                    
                
                
            

        

        
    


    
    












    

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