L-Arginine ： Heart Failure
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
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D
結論
Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.
Key Study Findings
Review
Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Humans (general)
animal_study
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)
vs: Placebo
効果: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in
not_reported
In Vitro
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
Dose: astaxanthin
vs: L-NAME-induced preeclamptic rats
Outcome: oxidative stress and blood pressure
効果: reduced ROS and improved cell survival
None
対象集団: Preeclamptic rat model and HUVECs
In Vitro
1.0 weeks
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
Dose: 10 mg/kg
vs: None
Outcome: anxiety
効果: None
p < 0.05
対象集団: patients with anxiety
Other
1.0 weeks
Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …
Dose: None
vs: None
Outcome: Nitric oxide modulation mediates the protective effect of …
効果: None
p<0.05
対象集団: None
Review
Immunonutrition.
Dose: Glutamine, omega-3, antioxidants, arginine
vs: None
Outcome: Immune function and clinical outcomes
効果: None
None
対象集団: Surgical, ICU, cancer, Crohn's disease patients
Key Statistics
3
研究数
150
参加者数
↔
Mixed
D
グレード
Referenced Papers
Advances in experimental …
2021
206 件の引用
Journal of ethnopharmacology
2021
18 件の引用
Molecular medicine reports
2016
48 件の引用
Indian journal of …
2011
11 件の引用
Pharmacological reports : …
2008
Immunonutrition.
Review
Current opinion in …
2005
22 件の引用
Arginine and cancer.
Review
The Journal of …
2004
181 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- endothelialfunction:
- 3,000-6,000 mg/day
- bloodpressuresupport:
- 6,000-10,000 mg/day divided BID-TID
上限量： Not formally established; GI discomfort common above 10,000 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) | -- | Positive | -- |
| astaxanthin | -- | Positive | -- |
| 10 mg/kg | 1.0 weeks | Positive | -- |
| None | 1.0 weeks | Mixed | -- |
| Glutamine, omega-3, antioxidants, arginine | -- | Positive | -- |
| L-arginine | -- | Mixed | -- |
推奨摂取タイミング： On empty stomach for best absorption; divide doses throughout the day
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Hypotension at high doses
- ⚠ Worsening of herpes simplex (arginine promotes viral replication)
- ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)
既知の相互作用
- ● Antihypertensives (additive blood pressure lowering)
- ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
- ● Nitrates (excessive vasodilation risk)
- ● Anticoagulants (may have mild antiplatelet effect)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
耐容上限摂取量： Not formally established; GI discomfort common above 10,000 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does L-Arginine help with Heart Failure?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).
How much L-Arginine should I take for Heart Failure?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Arginine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Arginine and Heart Failure?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
に関する他の成分： Heart Failure
L-Arginine 他の症状・状態について
References
- [1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
- [3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
- [4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
- [5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
- [6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
- [7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed
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