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L-Arginine ： Endothelial Dysfunction

C

Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

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            C

        

        

            
結論

            
            
Research suggests improvement in FMD and blood pressure. However, the VINTAGE MI trial showed potential harm in acute MI patients. Generally considered safe in stable patients, but should be avoided post-MI.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
11

        
研究数

    

    

        
600

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
グレード

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
endothelialfunction:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
6,000-10,000 mg/day divided BID-TID

                    

                    
                

                
                

                    上限量： Not formally established; GI discomfort common above 10,000 mg/day
                

                
            

            

            

            
            

                推奨摂取タイミング： On empty stomach for best absorption; divide doses throughout the day
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea, bloating)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hypotension at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Worsening of herpes simplex (arginine promotes viral replication)
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential harm in acute post-MI patients (VINTAGE MI concern)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (sildenafil — excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Nitrates (excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may have mild antiplatelet effect)
                        
    • 
                        
                        
  • 
                            ●
                            Potassium-sparing diuretics (arginine may increase potassium levels)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not formally established; GI discomfort common above 10,000 mg/day
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Arginine help with Endothelial Dysfunction?
            
        
        

            Based on 11 studies with 600 participants, there is limited but promising evidence that L-Arginine may support Endothelial Dysfunction management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Arginine should I take for Endothelial Dysfunction?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Arginine?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Arginine and Endothelial Dysfunction?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 11 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
に関する他の成分： Endothelial Dysfunction

                    

                        
                        
                            Cocoa Flavanols
                            A

                        
                        
                        
                            Grape Seed Extract
                            C

                        
                        
                        
                            Astaxanthin
                            D

                        
                        
                    

                

                

                
                

                    
L-Arginine 他の症状・状態について

                    

                        
                        
                            Heart Failure
                            D

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。