Taurine ： Heart Failure
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Small RCTs show improved exercise capacity and cardiac function. Mechanistically compelling as the most abundant free amino acid in the heart. Larger trials are needed.
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C
結論
Small RCTs show improved exercise capacity and cardiac function. Mechanistically compelling as the most abundant free amino acid in the heart. Larger trials are needed.
Key Study Findings
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
vs: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
効果: None
p<0.05
対象集団: female rats with water avoidance stress-induced IBS-D model
Controlled Clinical Trial
6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day
vs: ROFA exposure without taurine
Outcome: Multi-organ oxidative stress and neuroinflammation
効果: None
None
対象集団: Male Wistar rats with intranasal ROFA exposure
Review
Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice
vs: HFD control mice
Outcome: Cognitive function (Y-maze, MWM, novel object recognition)
効果: None
None
対象集団: HFD-induced obese male C57BL/6 mice
Other
Transcriptomics study of hippocampus in mice exposed to heat stress.
Dose: None
vs: Heat stress without taurine
Outcome: Hippocampal gene expression and cognitive function
効果: None
None
対象集団: Mice exposed to heat stress
Other
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Dose: None
vs: None
Outcome: None
効果: None
p < .05
対象集団: Insomnia patients
Key Statistics
4
研究数
200
参加者数
↑
Positive
C
グレード
Referenced Papers
Journal of the …
2026
Frontiers in nutrition
2025
7 件の引用
Clinical nutrition (Edinburgh, …
2025
1 件の引用
Psychoneuroendocrinology
2025
1 件の引用
Neurotoxicology
2025
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Other
PloS one
2024
5 件の引用
Toxicological sciences : …
2022
29 件の引用
Journal of proteome …
2006
80 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 1,000-3,000 mg/day
- heartfailuresupport:
- 2,000-3,000 mg/day
- bloodpressuresupport:
- 1,500-3,000 mg/day
上限量： EFSA considers 6,000 mg/day safe; up to 6,000 mg/day used in clinical trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| 400 mg/kg/day | 6 weeks | Mixed | -- |
| None | -- | Mixed | -- |
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： Can be taken with or without food; divide doses >2,000 mg
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated even at high doses
- ⚠ Mild gastrointestinal discomfort (rare)
- ⚠ Drowsiness (mild, at high doses)
既知の相互作用
- ● Antihypertensives (additive blood pressure lowering)
- ● Lithium (may alter lithium excretion)
- ● Antiepileptic drugs (may modulate GABA activity)
耐容上限摂取量： EFSA considers 6,000 mg/day safe; up to 6,000 mg/day used in clinical trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Taurine help with Heart Failure?
Based on 4 studies with 200 participants, there is limited but promising evidence that Taurine may support Heart Failure management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Heart Failure?
Studies have used various dosages. A commonly studied range is 1,000-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally well-tolerated even at high doses, Mild gastrointestinal discomfort (rare), Drowsiness (mild, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Heart Failure?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Heart Failure
Taurine 他の症状・状態について
References
- [1] Nazila Dardmeh et al.. J Sci Food Agric. 2026. Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … doi:10.1002/jsfa.70190 PubMed
- [2] Apeksha Rana et al.. Front Nutr. 2025. Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. doi:10.3389/fnut.2025.1534000 PubMed
- [3] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
- [4] Bin Li et al.. Psychoneuroendocrinology. 2025. Transcriptomics study of hippocampus in mice exposed to heat stress. doi:10.1016/j.psyneuen.2025.107279 PubMed
- [5] Gedaias Noronha da Silva et al.. Neurotoxicology. 2025. Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac tissues and promotes neuroinflammation, with … doi:10.1016/j.neuro.2025.103347 PubMed
- [6] Williams Kobik et al.. PLoS One. 2024. Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors. doi:10.1371/journal.pone.0289391 PubMed
- [7] David Scieszka et al.. Toxicol Sci. 2022. Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States. doi:10.1093/toxsci/kfab147 PubMed
- [8] Francois-Pierre J Martin et al.. J Proteome Res. 2006. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. doi:10.1021/pr060157b PubMed
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