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L-Arginine per Heart Failure

D Ricerca Esiste solo ricerca preliminare (studi di laboratorio, segnalazioni di casi).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

D

In sintesi

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

animal_study
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo Effetto: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported
In Vitro
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure Effetto: reduced ROS and improved cell survival

Popolazione: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
Dose: 10 mg/kg Outcome: anxiety p < 0.05

Popolazione: patients with anxiety

Review
Immunonutrition.
Dose: Glutamine, omega-3, antioxidants, arginine Outcome: Immune function and clinical outcomes

Popolazione: Surgical, ICU, cancer, Crohn's disease patients

Review
Arginine and cancer.
Dose: L-arginine Outcome: Cancer biology and NO role

Key Statistics

3

Studi

150

Partecipanti

↔

Mixed

D

Grado

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other
Advances in experimental … 2021 206 citazioni
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other
Journal of ethnopharmacology 2021 18 citazioni
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other
Molecular medicine reports 2016 48 citazioni
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other
Indian journal of … 2011 11 citazioni
Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other
Pharmacological reports : … 2008
Immunonutrition. Review
Current opinion in … 2005 22 citazioni
Arginine and cancer. Review
The Journal of … 2004 181 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

endothelialfunction:
3,000-6,000 mg/day
bloodpressuresupport:
6,000-10,000 mg/day divided BID-TID

Limite massimo: Not formally established; GI discomfort common above 10,000 mg/day

Dosaggi studiati nella ricerca

Dosaggio Durata Effetto N
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) -- Positive --
astaxanthin -- Positive --
10 mg/kg 1.0 weeks Positive --
Glutamine, omega-3, antioxidants, arginine -- Positive --
L-arginine -- Mixed --

Momento migliore per l'assunzione: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

Effetti collaterali segnalati

  • ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
  • ⚠ Hypotension at high doses
  • ⚠ Worsening of herpes simplex (arginine promotes viral replication)
  • ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

Interazioni note

  • ● Antihypertensives (additive blood pressure lowering)
  • ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
  • ● Nitrates (excessive vasodilation risk)
  • ● Anticoagulants (may have mild antiplatelet effect)
  • ● Potassium-sparing diuretics (arginine may increase potassium levels)

Livello di assunzione massimo tollerabile: Not formally established; GI discomfort common above 10,000 mg/day

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).
How much L-Arginine should I take for Heart Failure?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Arginine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Arginine and Heart Failure?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

L-Arginine per altre condizioni

Endothelial Dysfunction C

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References

  
    
    
    
  1. 
      [1]
      Guoyao Wu et al..
      Adv Exp Med Biol.
      2021.
      Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
      doi:10.1007/978-3-030-74180-8_10
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Priya Pathak et al..
      J Ethnopharmacol.
      2021.
      Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
      doi:10.1016/j.jep.2021.114296
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Rong-Rong Xuan et al..
      Mol Med Rep.
      2016.
      Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
      doi:10.3892/mmr.2016.5569
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Anil Kumar et al..
      Indian J Pharmacol.
      2011.
      Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
      doi:10.4103/0253-7613.81506
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Anil Kumar et al..
      Pharmacol Rep.
      2008.
      Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.
      
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Robert F Grimble.
      Curr Opin Gastroenterol.
      2005.
      Immunonutrition.
      doi:10.1097/01.mog.0000153360.90653.82
      PubMed
    
    7. 
    
    
  7. 
      [7]
      D Scott Lind.
      J Nutr.
      2004.
      Arginine and cancer.
      doi:10.1093/jn/134.10.2837S
      PubMed
    
    8. 
    
  















    

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        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.