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Taurine per Heart Failure

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Small RCTs show improved exercise capacity and cardiac function. Mechanistically compelling as the most abundant free amino acid in the heart. Larger trials are needed.

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C

In sintesi

Small RCTs show improved exercise capacity and cardiac function. Mechanistically compelling as the most abundant free amino acid in the heart. Larger trials are needed.

Key Study Findings

Other n=25 4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 vs: phosphate-buffered saline (PBS) Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores) Effetto: None p<0.05

Popolazione: female rats with water avoidance stress-induced IBS-D model

Controlled Clinical Trial 6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day vs: ROFA exposure without taurine Outcome: Multi-organ oxidative stress and neuroinflammation Effetto: None None

Popolazione: Male Wistar rats with intranasal ROFA exposure

Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Effetto: None None

Popolazione: HFD-induced obese male C57BL/6 mice

Other
Transcriptomics study of hippocampus in mice exposed to heat stress.
Dose: None vs: Heat stress without taurine Outcome: Hippocampal gene expression and cognitive function Effetto: None None

Popolazione: Mice exposed to heat stress

Other
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Dose: None vs: None Outcome: None Effetto: None p < .05

Popolazione: Insomnia patients

Key Statistics

4

Studi

200

Partecipanti

Positive

C

Grado

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:
1,000-3,000 mg/day
heartfailuresupport:
2,000-3,000 mg/day
bloodpressuresupport:
1,500-3,000 mg/day

Limite massimo: EFSA considers 6,000 mg/day safe; up to 6,000 mg/day used in clinical trials

Dosaggi studiati nella ricerca

Dosaggio Durata Effetto N
Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 4 weeks Positive 25
400 mg/kg/day 6 weeks Mixed --
None -- Mixed --
50 mg/kg lycopene in mice -- Positive --
None -- Positive --
None -- Neutral --
None -- Negative --
None -- Positive --

Momento migliore per l'assunzione: Can be taken with or without food; divide doses >2,000 mg

Safety & Side Effects

Effetti collaterali segnalati

  • Generally well-tolerated even at high doses
  • Mild gastrointestinal discomfort (rare)
  • Drowsiness (mild, at high doses)

Interazioni note

  • Antihypertensives (additive blood pressure lowering)
  • Lithium (may alter lithium excretion)
  • Antiepileptic drugs (may modulate GABA activity)

Livello di assunzione massimo tollerabile: EFSA considers 6,000 mg/day safe; up to 6,000 mg/day used in clinical trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Taurine help with Heart Failure?
Based on 4 studies with 200 participants, there is limited but promising evidence that Taurine may support Heart Failure management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Heart Failure?
Studies have used various dosages. A commonly studied range is 1,000-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally well-tolerated even at high doses, Mild gastrointestinal discomfort (rare), Drowsiness (mild, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Heart Failure?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

References

  1. [1] Nazila Dardmeh et al.. J Sci Food Agric. 2026. Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … doi:10.1002/jsfa.70190 PubMed
  2. [2] Apeksha Rana et al.. Front Nutr. 2025. Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. doi:10.3389/fnut.2025.1534000 PubMed
  3. [3] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
  4. [4] Bin Li et al.. Psychoneuroendocrinology. 2025. Transcriptomics study of hippocampus in mice exposed to heat stress. doi:10.1016/j.psyneuen.2025.107279 PubMed
  5. [5] Gedaias Noronha da Silva et al.. Neurotoxicology. 2025. Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac tissues and promotes neuroinflammation, with … doi:10.1016/j.neuro.2025.103347 PubMed
  6. [6] Williams Kobik et al.. PLoS One. 2024. Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors. doi:10.1371/journal.pone.0289391 PubMed
  7. [7] David Scieszka et al.. Toxicol Sci. 2022. Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States. doi:10.1093/toxsci/kfab147 PubMed
  8. [8] Francois-Pierre J Martin et al.. J Proteome Res. 2006. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. doi:10.1021/pr060157b PubMed

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