Selenium cho Oxidative Stress (Cardiovascular)
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
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B
Kết luận
KiSel-10 trial: 54% CV mortality reduction with combination selenium (200 mcg) + CoQ10 (200 mg) over 4 years. 12-year follow-up confirmed sustained benefit. Most relevant in selenium-deficient populations.
Key Study Findings
animal study
Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …
Dose: zinc and/or selenium supplementation; doses not specified in abstract
so với: Placebo
Hiệu quả: None
None
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A …
Dose: None
so với: None
Outcome: MASLD treatment and prevention
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with metabolic steatotic liver disease (review)
Review
Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: People with depression
preclinical animal study with human correlational observation
Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment.
Dose: oral administration; specific dose not reported in abstract
so với: Placebo
Hiệu quả: None
None
Review
The Role of Various Types of Diets in the Treatments of Depressive Disorders.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: Adults with depression
prospective controlled study
n=30
Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …
Dose: None
so với: Placebo
Hiệu quả: None
None
Key Statistics
3
Nghiên cứu
600
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
Environment international
2026
Biomaterials
2025
8 trích dẫn
Nutrients
2025
3 trích dẫn
Cutaneous and ocular …
2025
1 trích dẫn
Medicina (Kaunas, Lithuania)
2025
1 trích dẫn
Biogerontology
2025
International journal of …
2025
Molecules (Basel, Switzerland)
2024
13 trích dẫn
Food & function
2024
6 trích dẫn
Journal of dairy …
2024
4 trích dẫn
Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis.
Meta-Analysis
Biological trace element …
2024
2 trích dẫn
Nutrients
2023
75 trích dẫn
International journal of …
2023
45 trích dẫn
BMC endocrine disorders
2023
25 trích dẫn
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Review
Metabolites
2023
13 trích dẫn
Journal of animal …
2023
11 trích dẫn
Animals : an …
2023
7 trích dẫn
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Other
Antioxidants (Basel, Switzerland)
2023
5 trích dẫn
Antioxidants (Basel, Switzerland)
2022
13 trích dẫn
Animal bioscience
2022
9 trích dẫn
Journal of inflammation …
2021
34 trích dẫn
Biological trace element …
2021
18 trích dẫn
Nutricion hospitalaria
2021
10 trích dẫn
Redox biology
2020
184 trích dẫn
Environmental science and …
2020
79 trích dẫn
Molecules (Basel, Switzerland)
2019
472 trích dẫn
British journal of …
2019
14 trích dẫn
Advances in clinical …
2018
200 trích dẫn
Nutricion hospitalaria
2018
32 trích dẫn
JAMA neurology
2017
258 trích dẫn
Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium.
Review
Placenta
2016
23 trích dẫn
Biological trace element …
2015
1 trích dẫn
Free radical biology …
2013
208 trích dẫn
Molecular nutrition & …
2012
65 trích dẫn
Biological trace element …
2012
31 trích dẫn
Alcoholism, clinical and …
2012
19 trích dẫn
Journal of clinical …
2011
396 trích dẫn
Nutrition and cancer
2011
19 trích dẫn
Nutrition in clinical …
2008
125 trích dẫn
The American journal …
2000
472 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 55 mcg/day
- cardiovascularantioxidant:
- 100-200 mcg/day
Giới hạn trên: 400 mcg/day (risk of selenosis above this level)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| zinc and/or selenium supplementation; doses not specified in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| oral administration; specific dose not reported in abstract | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | 30 |
| None | -- | Negative | 2065 |
| None | -- | Positive | -- |
Thời điểm dùng tốt nhất: With meals
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
- ⚠ GI discomfort at moderate-high doses
- ⚠ Potential increased type 2 diabetes risk at high supplemental doses
Tương tác đã biết
- ● Cisplatin and other chemotherapy drugs (may affect efficacy)
- ● Statins (may enhance antioxidant effects)
- ● CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
Mức hấp thụ tối đa cho phép: 400 mcg/day (risk of selenosis above this level)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Selenium help with Oxidative Stress (Cardiovascular)?
Based on 3 studies with 600 participants, there is moderate evidence from clinical studies that Selenium may support Oxidative Stress (Cardiovascular) management. Our evidence grade is B (Good Evidence).
How much Selenium should I take for Oxidative Stress (Cardiovascular)?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Selenium?
Reported side effects may include Selenosis at high doses (garlic breath odor, hair/nail loss, nausea), GI discomfort at moderate-high doses, Potential increased type 2 diabetes risk at high supplemental doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Selenium and Oxidative Stress (Cardiovascular)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Oxidative Stress (Cardiovascular)
Selenium cho các tình trạng khác
References
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