L-Arginine para Heart Failure

Q: Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

Q: How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

D Pesquisa Existem apenas investigaciones preliminares (estudos laboratoriais, relatórios de casos).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

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Conclusão

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

Review

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Dose: None vs: None Outcome: None Efeito: None None

População: Humans (general)

animal_study

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …

Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo Efeito: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported

In Vitro

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure Efeito: reduced ROS and improved cell survival None

População: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.

Dose: 10 mg/kg vs: None Outcome: anxiety Efeito: None p < 0.05

População: patients with anxiety

Other 1.0 weeks

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …

Dose: None vs: None Outcome: Nitric oxide modulation mediates the protective effect of … Efeito: None p<0.05

População: None

Review

Immunonutrition.

Dose: Glutamine, omega-3, antioxidants, arginine vs: None Outcome: Immune function and clinical outcomes Efeito: None None

População: Surgical, ICU, cancer, Crohn's disease patients

Key Statistics

Estudos

150

Participantes

↔

Mixed

Nota

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 citações

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 citações

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other

Molecular medicine reports 2016 48 citações

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 citações

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Immunonutrition. Review

Current opinion in … 2005 22 citações

Arginine and cancer. Review

The Journal of … 2004 181 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

endothelialfunction:: 3,000-6,000 mg/day
bloodpressuresupport:: 6,000-10,000 mg/day divided BID-TID

Limite superior: Not formally established; GI discomfort common above 10,000 mg/day

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Mixed	--
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)	--	Positive	--
astaxanthin	--	Positive	--
10 mg/kg	1.0 weeks	Positive	--
None	1.0 weeks	Mixed	--
Glutamine, omega-3, antioxidants, arginine	--	Positive	--
L-arginine	--	Mixed	--

Melhor horário: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
⚠ Hypotension at high doses
⚠ Worsening of herpes simplex (arginine promotes viral replication)
⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

Interações Conhecidas

● Antihypertensives (additive blood pressure lowering)
● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
● Nitrates (excessive vasodilation risk)
● Anticoagulants (may have mild antiplatelet effect)
● Potassium-sparing diuretics (arginine may increase potassium levels)

Ingestão máxima tolerável: Not formally established; GI discomfort common above 10,000 mg/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Outros ingredientes para Heart Failure

Coenzyme Q10 (CoQ10) B Hawthorn B Vitamin D C Taurine C PQQ (Pyrroloquinoline Quinone) D NMN (Nicotinamide Mononucleotide) D

L-Arginine para outras condições

Endothelial Dysfunction C

Veredito Rápido

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Evidence Strength30%

Low confidence

Detalhamento dos Estudos

RCT (0)Meta (0)Other (3)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Heart Failure

Saiba Mais

References

[1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
[3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
[4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
[5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
[6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
[7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.

L-Arginine para Heart Failure

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Conclusão

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosagens Comumente Utilizadas

Dosagens Estudadas em Pesquisas

Safety & Side Effects

Efeitos Colaterais Relatados

Interações Conhecidas

Frequently Asked Questions

Related Evidence

Outros ingredientes para Heart Failure

L-Arginine para outras condições

References