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HeartCited

Niacin (Vitamin B3) ： High Cholesterol (Hyperlipidemia)

B

Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

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            B

        

        

            
結論

            
            
Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
10

        
研究数

    

    

        
12000

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
generalnutrition:

                        
14-16 mg/day

                    

                    
                    

                        
lipidmodification:

                        
1,000-2,000 mg/day (start at 500 mg/day and titrate)

                    

                    
                

                
                

                    上限量： 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                

                
            

            

            

            
            

                推奨摂取タイミング： With dinner or at bedtime with a low-fat snack; aspirin 30 min before may reduce flushing
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Flushing (redness, warmth, itching — most common, especially immediate-release)
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hepatotoxicity (especially extended-release at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperglycemia (may worsen blood sugar control)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperuricemia (may precipitate gout)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Statins (increased risk of myopathy/rhabdomyolysis)
                        
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  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may counteract blood sugar control)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Alcohol (may worsen flushing and hepatotoxicity)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Niacin (Vitamin B3) help with High Cholesterol (Hyperlipidemia)?
            
        
        

            Based on 10 studies with 12,000 participants, there is moderate evidence from clinical studies that Niacin (Vitamin B3) may support High Cholesterol (Hyperlipidemia) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Niacin (Vitamin B3) should I take for High Cholesterol (Hyperlipidemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 14-16 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Niacin (Vitamin B3)?
            
        
        

            Reported side effects may include Flushing (redness, warmth, itching — most common, especially immediate-release), Gastrointestinal discomfort (nausea, diarrhea), Hepatotoxicity (especially extended-release at high doses), Hyperglycemia (may worsen blood sugar control). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Niacin (Vitamin B3) and High Cholesterol (Hyperlipidemia)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 12,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Niacin (Vitamin B3) 他の症状・状態について

                    

                        
                        
                            High Triglycerides (Hypertriglyceridemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。