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Red Yeast Rice ： High Cholesterol (Hyperlipidemia)

A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。

CCSPS trial (4,870 post-MI): 45% MI reduction, 33% mortality reduction. Contains monacolin K (lovastatin). Strong efficacy for LDL reduction but significant regulatory and quality control concerns.

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結論

            
            
CCSPS trial (4,870 post-MI): 45% MI reduction, 33% mortality reduction. Contains monacolin K (lovastatin). Strong efficacy for LDL reduction but significant regulatory and quality control concerns.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                12 weeks
                
                
            

            
                Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A …
            
            

                
                Dose: 190 mg/d
                
                
                vs: None
                
                
                Outcome: Cholesterol levels
                
                
                効果: None
                
                
                p < 0.01
                
            

            
            
対象集団: Aged individuals

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                8 weeks
                
                
                Double-blind
                
            

            
                Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers …
            
            

                
                Dose: 180 mg/d
                
                
                vs: None
                
                
                Outcome: lipid levels
                
                
                効果: None
                
                
                p < 0.001
                
            

            
            
対象集団: Patients with dyslipidemia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
22

        
研究数

    

    

        
8000

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        A

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        5 件の引用
                        
                    

                

                
                

                    

                        
                            Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2023
                        
                        8 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
1,200-2,400 mg/day providing 10 mg monacolin K

                    

                    
                    

                        
lipidsupport:

                        
600 mg BID

                    

                    
                

                
                

                    上限量： EU-regulated maximum: 10 mg monacolin K/day; quality varies dramatically between products
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                190 mg/d
                                12 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                180 mg/d
                                8 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With dinner (cholesterol synthesis peaks overnight)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Myalgia (muscle pain — same mechanism as statins)
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Elevated liver enzymes (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Citrinin contamination risk in poorly manufactured products
                        
    • 
                        
                        
  • 
                            ⚠
                            Rhabdomyolysis (rare, at high doses)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Statins (contraindicated — same mechanism, additive myopathy risk)
                        
    • 
                        
                        
  • 
                            ●
                            CYP3A4 inhibitors (grapefruit juice, certain antibiotics — increased monacolin K levels)
                        
    • 
                        
                        
  • 
                            ●
                            Fibrates (increased myopathy risk)
                        
    • 
                        
                        
  • 
                            ●
                            Cyclosporine (increased myopathy risk)
                        
    • 
                        
                        
  • 
                            ●
                            Niacin (increased myopathy risk at high doses)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： EU-regulated maximum: 10 mg monacolin K/day; quality varies dramatically between products
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Red Yeast Rice help with High Cholesterol (Hyperlipidemia)?
            
        
        

            Based on 22 studies with 8,000 participants, there is strong evidence from multiple clinical trials that Red Yeast Rice may support High Cholesterol (Hyperlipidemia) management. Our evidence grade is A (Strong Evidence).
        

    

    
    

        
            How much Red Yeast Rice should I take for High Cholesterol (Hyperlipidemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 1,200-2,400 mg/day providing 10 mg monacolin K. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Red Yeast Rice?
            
        
        

            Reported side effects may include Myalgia (muscle pain — same mechanism as statins), Gastrointestinal discomfort, Elevated liver enzymes (rare), Citrinin contamination risk in poorly manufactured products. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Red Yeast Rice and High Cholesterol (Hyperlipidemia)?
            
        
        

            We rate the evidence as Grade A (Strong Evidence). This rating is based on 22 peer-reviewed studies with 8,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Evgeny Pokushalov et al..
      Nutrients.
      2024.
      Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study.
      doi:10.3390/nu16132023
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Nicholas Angelopoulos et al..
      Nutrients.
      2023.
      Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with …
      doi:10.3390/nu15122682
      PubMed
    
    3. 
    
  















    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。