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Niacin (Vitamin B3) 관련 High Cholesterol (Hyperlipidemia)

B

Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

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            B

        

        

            
결론

            
            
Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
10

        
연구

    

    

        
12000

        
참여자

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
등급

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
일반적으로 사용되는 용량

                

                    
                    

                        
generalnutrition:

                        
14-16 mg/day

                    

                    
                    

                        
lipidmodification:

                        
1,000-2,000 mg/day (start at 500 mg/day and titrate)

                    

                    
                

                
                

                    상한량: 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                

                
            

            

            

            
            

                권장 복용 시간: With dinner or at bedtime with a low-fat snack; aspirin 30 min before may reduce flushing
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
보고된 부작용

                    
    
                        
                        
  • 
                            ⚠
                            Flushing (redness, warmth, itching — most common, especially immediate-release)
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hepatotoxicity (especially extended-release at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperglycemia (may worsen blood sugar control)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperuricemia (may precipitate gout)
                        
    • 
                        
                    

                

                

                
                

                    
알려진 상호작용

                    
    
                        
                        
  • 
                            ●
                            Statins (increased risk of myopathy/rhabdomyolysis)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may counteract blood sugar control)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Alcohol (may worsen flushing and hepatotoxicity)
                        
    • 
                        
                    

                

                

                
                

                    

                        일일 최대 섭취 허용량: 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                    

                

                
            

            

                건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Niacin (Vitamin B3) help with High Cholesterol (Hyperlipidemia)?
            
        
        

            Based on 10 studies with 12,000 participants, there is moderate evidence from clinical studies that Niacin (Vitamin B3) may support High Cholesterol (Hyperlipidemia) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Niacin (Vitamin B3) should I take for High Cholesterol (Hyperlipidemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 14-16 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Niacin (Vitamin B3)?
            
        
        

            Reported side effects may include Flushing (redness, warmth, itching — most common, especially immediate-release), Gastrointestinal discomfort (nausea, diarrhea), Hepatotoxicity (especially extended-release at high doses), Hyperglycemia (may worsen blood sugar control). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Niacin (Vitamin B3) and High Cholesterol (Hyperlipidemia)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 12,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Niacin (Vitamin B3) 다른 건강 상태에 대한 근거

                    

                        
                        
                            High Triglycerides (Hypertriglyceridemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.